Search for dissertations about: "TMRCA"

Found 5 swedish dissertations containing the word TMRCA.

  2. 1. Inferring Evolutionary Processes of Humans

    Author : Sen Li; Mattias Jakobsson; Ludovic Orlando; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Approximate Bayesian Computation; TMRCA; demography; human evolution; Bantu-Expansion; Out-of-Africa;

    Abstract : More and more human genomic data has become available in recent years by the improvement of DNA sequencing technologies. These data provide abundant genetic variation information which is an important resource to help us to understand the evolutionary history of humans. READ MORE

  4. 2. Assays for monitoring HIV therapy in low-middle income countries

    Author : Eva Agneskog; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The purpose of this thesis was to develop and/or evaluate assays for HIV viral load (VL) monitoring and HIV drug resistance testing of potential importance for research studies and clinical care in low- and middle income countries (LMICs). This was achieved using reverse transcriptase based (RT) assays and blood samples from Vietnamese and Swedish HIV-1 infected patients. READ MORE

  5. 3. Antiretroviral therapy among HIV-infected persons in northeastern Vietnam : impact of peer support on virologic failure and mortality in a cluster randomized controlled trial

    Author : Cuong Do Duy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV;

    Abstract : Background: Wide access to antiretroviral therapy (ART) has substantially improved the prognosis of patients living with HIV/AIDS (PLHIV). However, in resource-limited countries, sustaining ART programs to prevent drug resistance and treatment failure and to maximize the existing human resources is still challenging. READ MORE

  6. 4. The hepatitis B virus – Insights into genetic variability, evolution and Bayesian phylogeographic inference

    Author : Mikael Ingman; Malmö Klinisk virologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatit B; evolutionsbiologi; fylogeni; Hepatitis B; evolutionary dynamics; Phylogeography;

    Abstract : In terms of genome size, the hepatitis B virus is the smallest virus known to infect humans and its compactness with multiple overlapping reading frames puts restraints on the emergence of mutations. In the papers included in this thesis we aimed to investigate genetic variation within the precore and core promoter region and to describe the origin, spread and diversification of HBV genotype A. READ MORE

  7. 5. Translational genomics of HIV-1 subtype C in India : molecular phylogeny and drug resistance

    Author : Ujjwal Neogi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis describes the translational genomics of HIV-1subtype C in India from its origin to therapeutic response with the aim to improve our knowledge for better therapeutic and preventive strategies to combat HIV/AIDS. In a systemic approach, we identified the molecular phylogeny of HIV-1 subtypes circulating in India and the time to most recent common ancestors (tMRCA) of predominant HIV-1 subtype C strains. READ MORE