Search for dissertations about: "TNF inhibition"

Showing result 16 - 20 of 93 swedish dissertations containing the words TNF inhibition.

  2. 16. Studies on fat cell function in human obesity and insulin resistance

    Author : Patrik Löfgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Fat cell; lipolysis; lipogenesis; leptin; obesity; perilipin; polymorphism; post-obese; TNF-alpha; weightreduction.;

    Abstract : Enlarged fat cells, due to excess tri-glyceride (TG) stores with increased basal lipolysis (TG breakdown) and blunted action of the major regulatory hormones of fat cell metabolism (catecholamines and insulin) are hallmarks of common obesity in humans. It is, however, not known whether these aberrations are caused by obesity per se or is a consequence of obesity. READ MORE

  4. 17. New treatment strategies for growth failure caused by chronic inflammation in children

    Author : Paola Fernández Vojvodich; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic inflammation during childhood often leads to impaired bone growth and reduced height in adulthood. Interleukin-1β (IL-1β), interleukin-6 (IL-6) and the tumour necrosis factor-α (TNF-α) are pro-inflammatory cytokines up-regulated during chronic inflammation. READ MORE

  5. 18. Cytokines and cytokine-directed intervention in experimental arthritis

    Author : Karin Palmblad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : pro-inflammatory cytokines; collagen-induced arthritis; CNI-1493; HMG-1;

    Abstract : Rheumatoid arthritis (RA) is a common chronic autoimmune and inflammatory disease. Although the etiology of RA remains unknown, a general understanding of the pathogenesis is steadily increasing. The macrophage products tumor necrosis factor (TNF) and interleukin 1 (IL-1) are recognized as pivotal mediators in the arthritic process. READ MORE

  6. 19. Inflammation and neutrophil recruitment in healing of colonic anastomosis

    Author : Peter Månsson; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; experimetnal; anastomotic healing; Inflammation; neutrophil redruitment; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Abstract : Wound healing is a multistep process with an initial inflammatory response, followed by synthesis of extracellular matrix components and finalized by a repair phase. One main goal was to determine the impact and adhesive mechanisms of neutrophil recruitment in anastomotic healing in the colon. READ MORE

  7. 20. Pulmonary Injury Following Intestinal Ischemia and Reperfusion in Rats

    Author : Anna Börjesson; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reperfusion injury; intestinal ischemia; pulmonary injury; endothelium; cytokines; alveolar fluid clearance; leukocytes; orthopaedics; Surgery; traumatology; ortopedi; Kirurgi; traumatologi;

    Abstract : Intestinal ischemia and reperfusion (I/R) is a potentially life-threatening condition, sometimes leading to a systemic inflammatory response and the potential development of the multiple organ dysfunction syndrome. The overall aim of the thesis was to study the effects of intestinal I/R on pulmonary function with special emphasis on removal of excess alveolar fluid, pulmonary endothelial barrier permeability, leukocyte accumulation and function, and possible therapeutic strategies to prevent the development of pulmonary injury following intestinal I/R. READ MORE