Search for dissertations about: "TNF- a"

Showing result 1 - 5 of 610 swedish dissertations containing the words TNF- a.

  1. 1. Staphylococcal surface display in directed evolution

    Author : Nina Kronqvist; Stefan Ståhl; Mats A. A. Persson; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; affibody; combinatorial library; directed evoluation; Gram-positive bacteria. protein engineering; Bioengineering; Bioteknik;

    Abstract : Engineered affinity proteins have together with naturally derived antibodies becomeindispensable tools in many areas of life-science and with the increasing number ofapplications, the need for high-throughput methods for generation of such different affinityproteins is evident. Today, combinatorial protein engineering is the most successful strategy toisolate novel non-immunoglobulin affinity proteins. READ MORE

  2. 2. Purine synthesis inhibition in experimental lupus

    Author : Charlotte A Jonsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : SLE; Mycophenolate mofetil; MRLlpr lpr mice; cytokine; autoantibody;

    Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease that mainly affects women. The effect of the immune modulating drug mycophenolate mofetil (MMF) on experimental SLE was investigated. READ MORE

  3. 3. Mechanisms of dendritic cell maturation induced by intracellular bacteria infection

    Author : Miguel A. Tam; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Listeria; Salmonella; dendritic cells; maturation; MyD88; IFN-? ?;

    Abstract : Dendritic cells (DCs) are essential for the development of an immune response against pathogens such as Listeria monocytogenes and Salmonella typhimurium. This is mostly because of their unique capacity to stimulate naïve T cells. READ MORE

  4. 4. Modulaton of gene expression in human aortic smooth muscle cells by Porphyromonas gingivalis : a possible association between periodontitis and atherosclerosis

    Author : Boxi Zhang; Torbjörn Bengtsson; Allan Sirsjö; Hazem Khalaf; Julia Davies; Örebro universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microarray; Angiopoietin; Smooth muscle cells; TNF; Periodontitis; Atherosclerosis; Porphyromonas gingivalis; Cancer; Inflammasome; Biomedicin; Biomedicine;

    Abstract : Porphyromonas gingivalis is a gram-negative, rod-shaped, and anaerobic bacterium that is involved in the pathogenesis of periodontitis. P. gingivalis produces a variety of virulence factors including gingipains and fimbriae. READ MORE

  5. 5. Cannabinoids as neuroprotective agents : a mechanistic study

    Author : Olov Nilsson; Christopher Fowler; Edward Högestätt; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cannabinoid; neuroprotection; inflammation; cytokine; neutrophil; Pharmacology; Farmakologi;

    Abstract : Glucose and oxygen supply to the brain is critical for its proper function and when it is restricted as during a stroke, neurons and glial cells quickly become necrotic leading to structural damage as well as functional impairment and even death. To date there are few effective therapies that inhibit the neurodegenerative process and improves the outcome for the affected individual. READ MORE