Search for dissertations about: "TNF- a"
Showing result 11 - 15 of 633 swedish dissertations containing the words TNF- a.
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11. p38 MAPK Signalling in Endothelial Apoptosis
Abstract : Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main target of which is the endothelium, and by the anticancer drug doxorubicin. READ MORE
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12. Cytokines in Staphylococcus aureus arthritis. For better for worse
Abstract : Septic arthritis is an inflammatory condition in joints caused by in situ residing bacteria accompanied by a septic reaction. Bacteria reach their target via the blood stream and the major human pathogen is Staphylococcus aureus. READ MORE
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13. Islet xenotransplantation : An immunological study in the pig-to-mouse model
Abstract : Successful clinical xenotransplantation, i.e., transplantation between species, would eliminate the shortage of donor organs. In order to study the acute cellular rejection reaction following discordant xenogeneic transplantation, an experimental pig-to- mouse islet xenotransplantation model was established. READ MORE
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14. Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
Abstract : Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. READ MORE
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15. Regulation of the platelet-derived growth factor β-receptor
Abstract : Growth factors are important signalling molecules, regulating cell growth, as well as cell movement, differentiation and apoptosis. They bind to specific receptors on the cell surface causing activation of the receptors. Activated receptors then attract adaptor molecules that brings the signal further into the cell. READ MORE