Search for dissertations about: "TNF-alpha in normal human"

Showing result 1 - 5 of 15 swedish dissertations containing the words TNF-alpha in normal human.

  2. 1. The involvement of the TNF-alpha system in skeletal muscle in response to marked overuse

    Author : Lina Renström; Sture Forsgren; Per Stål; Håkan Alfredson; Eva Ekblad; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF-alpha; TNFR1; TNFR2; muscle damage; myositis; peritendinous tissue; tendinopathy;

    Abstract : Painful conditions having the origin within the musculoskeletal system is a common cause for people to seek medical care. Between 20-40% of all visits to the primal care in Sweden are coupled to pain from the musculoskeletal system. Muscle pain and impaired muscle function can be caused by muscles being repetitively overused and/or via heavy load. READ MORE

  4. 2. TNF-α and neurotrophins in Achilles tendinosis

    Author : Johan Bagge; Sture Forsgren; Tomas Movin; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; tendinosis; tendinopathy; neurotrophins; TNF-alpha; physical acitivity; apoptosis; proliferation; pain; remodelling; anatomi; Human Anatomy;

    Abstract : Tenocytes are the principal cells of the human Achilles tendon. In tendinosis, changes in the metabolism and morphology of these cells occur. Neurotrophins are growth factors essential for the development of the nervous system. READ MORE

  5. 3. Effects of Biomechanical Stress on Gene Regulation in Vascular Cells

    Author : Maria Carlström; Göteborgs universitet; []
    Keywords : shear stress; intraluminal pressure; endothelium; gene expression; DNA microarray; real-time RT-PCR; reference genes; smooth muscle cells; P2 receptors; TNF-alpha; urokinase-type plasminogen activator;

    Abstract : The vascular vessel wall is constantly exposed to biomechanical forces, such as shear and tensile stress. Biomechanical forces are important for several physiological and pathological processes and have been shown to regulate a number of fundamental vascular functions, such as vascular tone and remodeling processes. READ MORE

  6. 4. Mechanisms of immune dysfunction in human lymphomas

    Author : Jan Sjöberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Accumulating data suggest that tumor-induced immune dysfunction counteracts presumptively efficient tumor-specific immune responses, and thus contributes to disease progression. In the present work, focus was given on immune dysfunction and the underlying mechanisms in two human lymphomas, Hodgkin's disease (HD) and B cell chronic lymphocytic leukemia (B-CLL). READ MORE

  7. 5. Effect of Drugs on Rabbit Retina

    Author : Anna Cardiakidis Myers; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug toxicity; electroretinography; histopathology; intravitreal injection; rifabutin; anti-VEGF; triamcinolone; benzyl alcohol; anti-TNF-alpha; adalimumab;

    Abstract : The adverse effects of drugs in the eye are not easily detected, and the underlying pathogenesis not fully understood. The effects of four different kinds of drugs have been investigated in the rabbit eye, using electroretinography, ocular examination and histochemical methods. READ MORE