Search for dissertations about: "TNFSF13"

Found 3 swedish dissertations containing the word TNFSF13.

2. 1. Functional Screens Identify Vulnerabilities in Acute Leukemia

   Author : Ramprasad Ramakrishnan; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; CRISPR; CXCR4; CXCL12; TNFSF13; DUX4; Interleukin 4; leukemia stem cell; macrophage;

   Abstract : Acute leukemia refers to a group of aggressive hematological malignancies of myeloid and lymphoid lineages termed acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) respectively. Acute leukemia is characterized by the presence of underlying genetic aberrations which alter the biology of normal hematopoietic cells resulting in the accumulation of immature abnormally differentiated blast cells. READ MORE

4. 2. Studies of Ligands and Receptors Regulating Acute Myeloid Leukemia

   Author : Pablo Peña; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Acute myeloid leukemia (AML) is the most common leukemia in adults and is coupled to a poor prognosis, with a five-year overall survival of around 20% and a high risk of relapse. In AML, immature myeloid cells accumulate rapidly in the bone marrow impairing normal blood cell development. READ MORE

5. 3. Identification and characterization of candidate therapeutic targets in acute myeloid leukemia

   Author : Mia Eriksson; Avdelningen för klinisk genetik; []
   Keywords : ;

   Abstract : Acute myeloid leukemia (AML) is a fatal disease that is characterized by a rapid expansion of myeloid leukemic blasts with impaired differentiation that accumulate in the bone marrow. The prognosis for AML is generally poor, with a five-year overall survival of around 20% in patients over 60 years old. READ MORE