Search for dissertations about: "TP53 mutation"

Showing result 16 - 20 of 40 swedish dissertations containing the words TP53 mutation.

  2. 16. Malignant melanoma of the vulva

    Author : Boel Ragnarsson Olding; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Malignant melanoma; Vulvar melanoma; mucosal melanoma; epidemiology; amelanotic melanoma; pre-existing nevus; N-Ras mutation; TP53 mutation;

    Abstract : From a consecutive, nationwide series of 219 females with primary vulvar malignant melanomas diagnosed in Sweden during 1960 to 1984 and followed up until 1994, we analyzed epidemiological, clinical, histopathological, prognostic and molecular genetic data. The age-standardized incidence among these patients, 75 % of whom were 60 years old or more, decreased by 3. READ MORE

  4. 17. Molecular studies in breast cancer susceptibility genes

    Author : Jindong Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : familial breast cancer; breast cancer susceptibility gene; BRCA1; BRCA2; ATM; TP53; PTEN MMAC1; STK11 LKB1; gene mutation; mutation screening; LOH;

    Abstract : Breast cancer is the most common malignancy among women, with a cumulative risk of approximately 12% by the age of 85. Of the breast cancer cases, 5-10% are hereditary. READ MORE

  5. 18. Prognostic markers in breast cancer associated with cell cycle control, proliferation and angiogenesis

    Author : Thomas Lindahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast cancer; TP53; VEGF; cyclin E; Ki-67; MIB-1; p21; MDM-2; survival; prognostic markers;

    Abstract : This thesis focuses on potential prognostic molecular breast cancer markers which are related to angiogenesis, proliferation or cell cycle control. A common denominator for all of the investigated markers in the thesis is either hypothesized or previously reported association with the tumor suppressor gene TP53. READ MORE

  6. 19. Oncogenes and tumour suppressor genes in human central nervous system tumours

    Author : Lu Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Human central nervous system (CNS) tumours may arise from both developing and adult brain. Primitive neuroectodermal tumours (PNETs) are the most malignant tumours arising from developing brain, and constitute approximately one third of brain tumours in children. Other common paediatric CNS tumours are ependymomas and pilocytic astrocytomas. READ MORE

  7. 20. Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53

    Author : Meiqiongzi Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows evasion of cell death and rapid tumor progression. READ MORE