Search for dissertations about: "TP53"
Showing result 16 - 20 of 90 swedish dissertations containing the word TP53.
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16. Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer
Abstract : The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations, resulting in the premature termination of translation and the production of truncated and non-functional p53 proteins. READ MORE
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17. Hunting a Silent Killer. Biomolecular Approaches in Ovarian Cancer
Abstract : Ovarian cancer is a heterogeneous disease and recent advances in improving patient outcome havebeen limited. It is estimated that a woman’s risk of developing ovarian cancer during her lifetime is about 1 in 70, making it a frequently occurring cancer type in women. READ MORE
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18. HER2 and TP53 in human breast cancer : studies of methods and prognostic value
Abstract : Prognostic and predictive factors are needed for tailored therapy strategies, aimed at reducing breast cancer relapse and improving survival. The present arsenal of such factors is insufficient. READ MORE
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19. Heritable TP53-related cancer syndrome in Sweden : characterisation of genotype-phenotype correlation and surveillance
Abstract : Around 25% of all cancers are considered as familial and are caused by an inherited susceptibility to develop certain tumours. But only 5-10% are hereditary and caused by known high risk cancer genes associated with specific cancer risk syndromes. READ MORE
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20. Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy
Abstract : A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. READ MORE