Search for dissertations about: "TPH2"

Found 5 swedish dissertations containing the word TPH2.

  2. 1. On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism

    Author : Susanne Henningsson; Göteborgs universitet; []
    Keywords : serotonin; 5-HTTLPR; TPH2; 5-HT3; sex steroids; androgen receptor; estrogen receptor; genetics; gene-gene interaction; social phobia; anxiety; premenstrual dysphoric disorder; depression; personality; autism; transsexualism; amygdala; emotional perception; life events;

    Abstract : Background: The neurotransmitter serotonin has been related to mood and anxiety, and variation in genes that encode important members of the serotonergic system may hence affect mood- and anxiety-related traits. Sex steroids influence brain development, and variation in genes encoding androgen and estrogen receptors, or enzymes needed for sex steroid synthesis, may be of importance for both personality traits and risk for psychiatric disorders. READ MORE

  4. 2. Mind really does matter : The Neurobiology of Placebo-induced Anxiety Relief in Social Anxiety Disorder

    Author : Vanda Faria; Tomas Furmark; Mats Fredrikson; Predrag Petrovic; Uppsala universitet; []
    Keywords : Placebo effect; anxiolysis; SAD; PET; TPH2 G-703T polymorphism; SSRIs; amygdala subregions; prefrontal cortex.; Psychology; Psykologi;

    Abstract : The placebo effect, a beneficial effect attributable to a treatment containing no specific properties for the condition being treated, has been demonstrated in a variety of medical conditions. This thesis includes four studies aimed at increasing our knowledge on the neurobiology of placebo. READ MORE

  5. 3. Experimental, mild blast-induced traumatic brain injury : focus on the monoamine and galanin systems

    Author : Lizan Kawa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Traumatic brain injury (TBI) is a common cause of mortality and morbidity among civilians and servicemen alike. The spectrum of TBIs encompasses mild to severe cases, with the predominate number of TBIs being mild (mTBI). Combat-related TBI inflicted by explosive blast (bTBI) is highly prevalent among military personnel. READ MORE

  6. 4. Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function

    Author : Alexander Balhuizen; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Estrogen; Serotonin; Pancreatic islets; Insulin resistance; Beta-cell function; GPCR;

    Abstract : Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). READ MORE

  7. 5. Neuropeptides in the human postmortem brain : focus on galanin and its receptors in depression

    Author : Swapnali Barde; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neuropeptides represent the most diverse family of messenger molecules in the nervous system, which are co-expressed with key neurotransmitters in several brain regions. They modulate synaptic neurotransmission and have, in some cases, also trophic functions. One such neuropeptide, and the focus of the thesis, is ‘galanin’. READ MORE