Search for dissertations about: "TRANSITION-STATE"
Showing result 1 - 5 of 98 swedish dissertations containing the word TRANSITION-STATE.
-
1. Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic
Abstract : HIV-1 protease inhibitors are important in the most frequently used regimen for the treatment of HIV/AIDS, the highly active antiretroviral therapy (HAART). For patients with access to this treatment, an HIV infection is no longer lethal, but rather a manageable, chronic infection. READ MORE
-
2. Protein Folding Studied by Site Directed Mutagenesis
Abstract : The N-terminal RNA binding domain of U1A has been shown to fold in a two-state process without accumulating any intermediates. U1A has a symmetrically curved chevron plot which seems to result mainly from changes of the transition state. READ MORE
-
3. Folding of the Ribosomal protein S6 : The role of sequence connectivity, overlapping foldons, and parallel pathways
Abstract : To investigate how protein folding is affected by sequence connectivity five topological variants of the ribosomal protein S6 were constructed through circular permutation. In these constructs, the chain connectivity (i.e. the order of secondary-structure elements) is changed without changing the native-state topology. READ MORE
-
4. Modelling of molybdopterin-dependent enzymes
Abstract : The thesis deals with models for molybdopterin-dependent enzymes. Several model systems containing molybdenum or tungsten have been prepared and characterised, and their reactivity with oxygen atom acceptors and donors have been investigated. READ MORE
-
5. Symmetry in Asymmetric Catalysis and Hydrogen Bond-Based Self-Assembly : Synthesis and Investigations
Abstract : The thesis elaborates on four different projects focusing on synthesizing symmetry-related molecules and investigating their performance as catalysts for asymmetric catalysis or as monomers for hydrogen bond-based self-assembly.Chapter 2 describes a new method to desymmetrize a meso-ligand. READ MORE