Search for dissertations about: "TRPV1 protein"

Showing result 1 - 5 of 10 swedish dissertations containing the words TRPV1 protein.

  2. 1. Activation and Regulation of TRPV1 : Studies in Recombinant Human Neuroblastoma TRPV1-SHSY5Y Cells

    Author : Johanna EL Andaloussi-Lilja; Anna Forsby; Antonio Ferrer-Montiel; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nociception; neurotrophic factors; eye irritation; stable transfection; Ca2 ; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : TRPV1 is a transmembrane non-selective cation channel with preference for Ca2+. The receptor is primarily localised on dorsal root ganglion neurons and is activated by numerous endogenous and exogenous potentially irritating ligands eliciting pain. READ MORE

  4. 2. Methods for elucidating membrane protein structure and function

    Author : Carolina Trkulja; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; patch clamp; antibodies; mass spectrometry; ion channels; proteomics; fluorescence; TRPV1; cholesterol.; limited proteolysis; Membrane proteins;

    Abstract : Elucidation of the structure-function relationship of membrane proteins increases our understanding of many biological processes, both physiological and pathological. However, membrane proteins have been notoriously difficult to study, having part of their structure embedded into the lipid cell membrane. READ MORE

  5. 3. Endogenous activators of the pain receptor TRPV1 From cell to man

    Author : Pouya Movahed Rad; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; cannabinoids; capsazepine; N-acylethanolamines; anandamide; blood Circulation; vasodilation; humans; calcitonin Gene-related Peptide; capsaicin; neurogenic inflammation; nociceptors; TRPV1 protein; pain;

    Abstract : N-acylethanolamines (NAEs) belong to a growing family of endogenous signalling molecules acting on a variety of receptors and ion channels. In 1992, it was reported that the N-acylethanolamine anandamide is present in the brain and activates the central cannabinoid (CB) receptor. READ MORE

  6. 4. Peripheral Regulation of Pain and Itch

    Author : Elín Ingibjörg Magnúsdóttir; Malin C. Lagerström; George H. Caughey; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain; itch; CGRP; TRPV1; mast cell; mast cell protease; mMCP4; mMCP6; CPA3; endothelin-1; compound 48 80; MRGPRX2; single-stranded oligonucleotide;

    Abstract : Pain and itch are diverse sensory modalities, transmitted by the somatosensory nervous system. Stimuli such as heat, cold, mechanical pain and itch can be transmitted by different neuronal populations, which show considerable overlap with regards to sensory activation. READ MORE

  7. 5. Microvascular inflammatory response in the skin

    Author : Vladimir Evilevitch; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; medicinsk instrumentering; Physiology; Fysiologi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; sodium nitroprusside; terbutaline; anandamide; TRPV1; skin prick test; vanilloid receptor; skin microcirculation; laser Doppler imaging; Plasma exudation; vasodilatation;

    Abstract : This thesis examines the microvascular inflammatory response in the skin. The microvascular response includes vasodilatation and plasma exudation. In the first three studies, the combined response was measured in guinea pig skin with a technique based on detection of radiolabelled protein. READ MORE