Search for dissertations about: "TSP-1"

Showing result 1 - 5 of 14 swedish dissertations containing the word TSP-1.

  2. 1. Influence of Islet-derived Factors in Islet Microcirculation and Endocrine Function

    Author : Carl Johan Drott; Per-Ola Carlsson; Leif Jansson; Albert Salehi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes mellitus; pancreas; blood flow; islet vascularity; islet-derived; TSP-1; ghrelin; CART; irisin; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Diabetes mellitus is a disorder with complex pathology and is frequently associated with vascular complications. In the islet micro milieu locally generated factors may affect both the physiology and the morphology of the tissue. READ MORE

  4. 2. Thrombospondin 1, an autocrine regulator in T cell adhesion and migration

    Author : ShuShun Li; Karl-Gösta Sundqvist; Jan Holgersson; Claes Dahlgren; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; T cell; adhesion; migration; thrombospondin; Immunologi; Immunology; Immunologi; immunologi; Immunology;

    Abstract : Lymphocytes, the principal cells of the immune system, perform the immune function throughout the body by their unique capacity to circulate in blood stream and lymphatic vessels and migrate in lymphoid and non-lymphoid tissues. The mechanisms regulating lymphocyte adhesion and migration, interactions with cells and components within the extracellular matrix are not fully understood. READ MORE

  5. 3. Role of Thrombospondin-1 in Endogenous and Transplanted Pancreatic Islets

    Author : Johan Olerud; Per-Ola Carlsson; Nils Welsh; Leif Jansson; Thierry Berney; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Type 1 diabetes mellitus is a severe life-long disease with a pronounced risk of developing secondary complications. One way to avoid the latter is to restore the fine tuning of blood glucose homeostasis by transplantation of pancreatic islets. READ MORE

  6. 4. Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility

    Author : Anna Forslöw; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human immune system, which protects the body from invading pathogens, largely depends on the proper function of lymphocytes, which are highly motile and constantly recirculate the blood and lymph. Adhesive and motile capability is often amplified or uncontrolled during chronic inflammatory conditions such as autoimmune diseases. READ MORE

  7. 5. Immunological studies on anca-associated vasculitis with special reference to T cell activation

    Author : Marta Christensson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis focuses on the role of T cells in ANCA-associated vasculitis. We initially investigated activation markers on T cells in patients with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and renal limited disease (RLD) and found increased expression indicating continuous activation despite clinical remission. READ MORE