Search for dissertations about: "TUNEL"

Showing result 11 - 15 of 45 swedish dissertations containing the word TUNEL.

  2. 11. Life without mitochondrial DNA : studies of transgenic mice

    Author : Jianming Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcripton factor A Tfam ; cre-loxP; conditional knockout; transgenic; mitochondrial cardiomyopathy; apoptosis;

    Abstract : Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription factor A (Tfam) is a key factor for transcription of mtDNA in vitro. READ MORE

  4. 12. Effects of Ischaemia on the Neuroretina and Retinal Blood Vessels

    Author : Bodil Gesslein; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein kinase C; tumor necrosis factor; mitogen-activated protein kinases; pig; blood vessels; mfERG; Retinal ischaemia; vascular endothelial growth factor; hypoxia-inducible factor;

    Abstract : Identification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. READ MORE

  5. 13. Functional studies of calcein acetoxymethyl ester in human tumor cells

    Author : Gunnar Liminga; Uppsala universitet; []
    Keywords : Medical sciences; Calcein AM; Calcein; Functional assay; Drug resistance; Cytotoxicity; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Abstract : A fluorometric assay for functional measurement of P-glycoprotein 170 (Pgp) mediated transport in cell lines, using the acetoxymethyl ester of calcein (calcein/AM) as a probe was established. The myeloma cell line RPMI 8226/S and the two Pgp-expressing doxorubicin resistant subcell lines 8226/dox6 (low) and 8226/dox40 (high) were used. READ MORE

  6. 14. Immunocytochemical visualization of cathepsin D during oxidative stress

    Author : Karin Roberg; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Cathepsin D is the major aspartic protease in lysosomes, and it is found in almost all animal cells. In the present studies, a pre-embedding immunocytochemical method was used to visualize cathepsin D in cultured cells. The protein can be detected at both light and electron microscopic levels by neutral-pH silver enhancement of ultrasmall (0. READ MORE

  7. 15. Transurethral microwave thermotherapy of benign prostatic hyperplasia : mechanisms of action and clinical outcome

    Author : Marianne Brehmer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : benign prostatic hyperplasia; transurethral microwave thermotherapy; clinical outcome; sham treatment; innervation; urethral sensitivity; necrosis; apoptosis; prostatic stromal cells in culture;

    Abstract : Background: The therapeutic value of transurethral microwave thermotherapy (TUMT) in benign prostatic hyperplasia (BPH) is a matter of debate. Aims: Evaluation of the clinical effect of TUMT and of various duration of the treatment; investigation of the kind and extent of tissue lesions induced by TUMT and of the mechanisms behind the therapeutic effect; investigation of the effect of heat on human prostate stromal cells in cell culture. READ MORE