Search for dissertations about: "Tads"
Found 4 swedish dissertations containing the word Tads.
-
1. Keeping track of time : Daily time management, participation, and time-related interventions for children, adolescents, and young adults with neurodevelopmental disorders
Abstract : The overall aim of this thesis was to investigate daily time management (DTM) and time-related interventions aiming to enhance participation in everyday activities among school-age children and young adults with neurodevelopmental disorders.In study I, experiences of participation when using time assistive devices (TADs) in daily activities were investigated from the perspective of young adults (aged 17–37) with intellectual disabilities (ID) (n = 9), using semi structured interviews. READ MORE
-
2. Mechanisms behind Smc5/6 transcriptional regulation and cohesin-mediated chromosome organisation
Abstract : The eukaryotic family of Structural Maintenance of Chromosomes (SMC) complexes are multi-subunit, ring-like protein complexes and include condensin, cohesin and the Smc5/6 complex (Smc5/6). Considered as an entity, this family is essential for most chromosome-based processes, and protects against diverse human syndromes and diseases. READ MORE
-
3. Beyond transcription : a post-transcriptional role of 3D chromatin crosstalk in oncogene regulation
Abstract : This thesis explores how stochastic chromatin fibre interactions, chromatin organization in the 3D nuclear architecture, and environmental signals collaborate to regulate MYC oncogene expression in human colon cancer cells. In Paper I, we employ the ultra-sensitive Nodewalk technique to uncover the dynamic and stochastic nature of chromatin networks impinging on MYC. READ MORE
-
4. Oxygen-dependent regulation of HIF-1alpha expression and function
Abstract : Hypoxia is a state of reduced oxygen levels below normal values. It occurs in the pathophysiology of many diseases and plays important roles in mammalian physiology and development. The hypoxia-inducible factors (HIFs) are transcription factors that mediate adaptive cellular responses to hypoxia by activating the transcription of target genes. READ MORE