Search for dissertations about: "Targeted adjuvant"
Showing result 1 - 5 of 31 swedish dissertations containing the words Targeted adjuvant.
-
1. Broadly protective nanoparticle-based mucosal vaccine against influenza virus infection
Abstract : Influenza is one of the major viral diseases affecting humans and it is responsible for three to five million cases of severe illness and about 250.000 to 500.000 deaths each year worldwide. READ MORE
-
2. MYC-driven Medulloblastoma : New Targeted Therapies and Mechanisms of Recurrence
Abstract : Medulloblastoma is the most common malignant brain tumor of childhood. It arises in the posterior fossa but presents with distinct histological and molecular features. Hence, medulloblastoma is divided into four molecular subgroups, WNT, SHH, Group 3, and Group 4. READ MORE
-
3. Proteasome targeted therapy in arthritis models : effects on pain and inflammation
Abstract : The ubiquitin proteasome system (UPS) regulates numerous cellular functions by selectively degrading cellular proteins. It controls activation of the transcription factor NF-ĸB which is involved in the expression of pro-inflammatory mediators. The UPS regulates neuronal signalling by controlling levels of synaptic proteins during chronic pain. READ MORE
-
4. Development of a targeted Drug Delivery System for treatment of Pancreatic Ductal Adenocarcinom
Abstract : Pancreatic cancer is the fourth leading cause of cancer-related death with a 5-year survival of less than 6%. The only potential cure for pancreatic cancer is by surgical removal of the tumor. However, most patients present with an advanced and metastasized disease at the time of diagnosis, leaving only around 15% of patients eligible for surgery. READ MORE
-
5. The development of a new combined adjuvant vector for mucosal immunization CTA1-DD/ISCOM
Abstract : The CTA1-DD/ISCOMs vector is a rationally designed mucosal adjuvant that was developed to host the distinctive properties of either adjuvant alone or in a combination that hosted additive enhancing effects on mucosal immune responses. Here I demonstrate that CTA1-DD can be incorporated into the ISCOM with greatly augmented immunogenicity of both incorporated and admixed antigen. READ MORE