Search for dissertations about: "Targeted protein degradation"

Showing result 1 - 5 of 63 swedish dissertations containing the words Targeted protein degradation.

2. 1. On bacterial formats in protein library technology

   Author : Per-Åke Löfdahl; Per-Åke Nygren; Mikael Widersten; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecule; β-lactamase; combinatorial library; green fluorescent protein GFP ; protein engineering; protein fragment complementation assay PCA ; selection; TEVprotease; TNF-α; Bioengineering; Bioteknik; Enzyme engineering; Enzymteknik;

   Abstract : Millions of years of evolution have resulted in an immense number of different proteins, which participate in virtually every process within cells and thus are of utmost importance for allknown forms of life. In addition, there are several examples of natural proteins which have found use in applications outside their natural environment, such as the use of enzymes infood industry and washing powders or the use of antibodies in diagnostic, bioseparation or therapeutic applications. READ MORE

4. 2. Protein phosphorylation and proteolysis - regulation and adaptive responses in photosynthesis

   Author : Jens Forsberg; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Växtbiokemi; proteolysis; Plant biochemistry; protease; two-component systems; protein kinase; protein phosphorylation; state transitions; light-harvesting antenna; photosynthesis; chloroplast;

   Abstract : Just as all other organisms, plants adapt to various environmental conditions. This work focuses on the role of chloroplast light harvesting complex II, LHCII, in adaptation of photosynthesis to changed light conditions. READ MORE

5. 3. Assessing the impact of modulating protein degradation pathways in cancer

   Author : Merve Kacal; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Proteins are macromolecules, essential constituents of the cells with various functions, such as providing structure to the cells, performing biochemical reactions, transporting molecules. The levels of cellular proteins are in a dynamic equilibrium and regulated by their synthesis and degradation rates. READ MORE

6. 4. Structural and functional investigation of underexplored carbohydrate-active enzyme families

   Author : Andrea Seveso; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; carbohydrate-active enzymes; lytic polysaccharide monooxygenase; plant biomass degradation; copper radical oxidases; carbohydrate esterase; protein structure determination; protein structure prediction;

   Abstract : The known consequences of the current fossil-based economy require a transition towards a bio-based economy. Development of biorefineries in which plant biomass can be utilized as a renewable source of energy and building blocks to produce both commodities and high-value products, is a key step in this transition. READ MORE

7. 5. Structural studies of drug targets and a drug metabolizing enzyme

   Author : Daniela Cederfelt; U. Helena Danielson; Doreen Dobritzsch; Inari Kursula; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biophysics; Protein structure; X-ray crystallography; Cryogenic electron microscopy; Enzymology; Drug discovery; Pyrimidine degradation; Biokemi; Biochemistry;

   Abstract : The work presented in this thesis describes how structural information about a protein can be acquired, and how it can be used to answer scientific questions about proteins’ function, their dynamic behaviour and their interactions with other proteins or ligands.The catalytic function of the pyrimidine-degrading, drug metabolizing enzyme β-ureidopropionase (βUP) is dependent on the shift between oligomeric states. READ MORE