Search for dissertations about: "Tau proteins"

Showing result 1 - 5 of 67 swedish dissertations containing the words Tau proteins.

2. 1. A stargazer's guide to neurodegeneration : Astrocytes' role in the propagation of pathological proteins

   Author : Tobias Mothes; Anna Erlandsson; Martin Ingelsson; Linn Streubel-Gallasch; Maria Grazia Spillantini; Uppsala universitet; []
   Keywords : Alzheimer’s disease; Parkinson’s disease; tauopathies; astrocyte; microglia; neuron; tau; amyloid-β; α-synuclein; accumulation; degradation; inflammation; spreading; seeding.; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of pathogenic protein aggregates. In the AD brain, amyloid-β (Aβ) and tau form plaques respective tangles, while in the PD brain α-synuclein (α-syn) form Lewy bodies and Lewy neurites. READ MORE

4. 2. Proximity Ligation and Barcoding Assays : Tools for analysis of proteins and protein complexes

   Author : Di Wu; Masood Kamali-Moghaddam; Ulf Landegren; Ola Söderberg; Jörg Hoheisel; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; proximity barcoding assay; sensitive; in situ; multiplex; profiling; amyloid-beta; MARK; tau; CSF; biomarker; protein complexes; Alzheimer’s disease; amyotrophic lateral sclerosis; Molekylär medicin; Molecular Medicine;

   Abstract : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. READ MORE

5. 3. Ex‘PLA’ining the progression of pathological proteins in Alzheimer’s and Parkinson’s diseases : see(d)ing is believing

   Author : Anish Behere; Joakim Bergström; Sara Ekmark-Lewén; Martin Ingelsson; Stina Syvänen; Hilal Lashuel; Uppsala universitet; []
   Keywords : Alpha synuclein; Tau; Proteoforms; Phosphorylation; Oligomers; Proximity Ligation Assay; sensitive detection of pathology; Alzheimer s disease; Parkinson s disease; pS129; pS202 pT205; pT231; PFFs;

   Abstract : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common forms of neurodegenerative disorders affecting approximately 50 million people worldwide. The underlying neuropathological processes leading to AD and PD share many similarities, i.e. aberrant protein aggregation of tau and alpha-synuclein (αSyn) in the brain. READ MORE

6. 4. Altered proteins in the aging brain

   Author : Adila Elobeid; Irina Alafuzoff; Lena Claesson-Welsh; Thomas Brännström; Uppsala universitet; []
   Keywords : Cognitively unimpaired subjects; Hyperphosphorylated tau; Beta amyloid; Alpha-synclein; Transactive response DNA binding protein 43; Patologi; Pathology;

   Abstract : The classification of neurodegenerative disorders is based on the major component of the protein aggregates in the brain. The most common altered proteins associated with neurodegeneration are Hyperphosphorylated tau (HPt), beta amyloid (Aβ), alpha-synclein (αS) and transactive response DNA binding protein 43 (TDP43). READ MORE

7. 5. Tau and neurofilament proteins in Alzheimer’s disease and related cell models

   Author : Cecilia Björkdahl; Karolinska Institutet; Karolinska Institutet; []
   Keywords : AD; tau; neurofilament proteins; kinases; zinc; Hsp27; alphaB-crystallin;

   Abstract : Background and aims: Among those afflicted with dementia more than half suffer from Alzheimer’s disease (AD). Pathological hallmarks of the disease include aggregates of Abeta, so called amyloid plaques, and neurofibrillary tangles (NFTs) made up of hyperphosphorylated cytoskeletal proteins. READ MORE