Search for dissertations about: "Taxanes and breast cancer"

Found 4 swedish dissertations containing the words Taxanes and breast cancer.

  2. 1. Pharmacometric Models for Antibody Drug Conjugates and Taxanes in HER2+ and HER2- Breast Cancer

    Author : Brendan Bender; Lena Friberg; Mats Karlsson; Jin Jin; Oscar della Pasqua; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometric; PKPD; model; breast cancer; T-DM1; thrombocytopenia; hepatotoxiticy; HER2; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : In oncology, there is a need to optimize drug treatment for efficient eradication of tumors, minimization of adverse effects (AEs), and prolonging patient survival. Pharmacometric models can be developed to streamline information between drug development phases, describe and quantify response to treatment, and determine dose regimens that balance toxicity and efficacy. READ MORE

  4. 2. Meta-analysis of randomized clinical evidence of chemotherapy, radiotherapy and endocrine therapy in breast cancer

    Author : Antonis Valachis; Vassilios Georgoulias; Dimitros Mavroudis; Gregory Chouverakis; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Meta -analysis; Bisphosphonates; Bevacizumab; Trastuzumab; Fulvestrant;

    Abstract :  Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide. Despite the growing body of randomized controlled trials (RCTs) regarding the use of various treatment strategies (chemotherapy, endocrine therapy, radiotherapy) in breast cancer, the efficacy of some strategies remains unclear and questionable. READ MORE

  5. 3. Investigating the treatment of metastatic breast cancer : real-world evidence on treatment patterns, safety and efficacy

    Author : Luisa Edman Kessler; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Metastatic breast cancer is an incurable disease causing a spectrum of symptoms and leading to a continuous deterioration of performance status and quality of life. It is a heterogeneous disease, with survival being related to tumor biology and patient-related factors. READ MORE

  6. 4. Studies of side effects related to adjuvant breast cancer regimens with focus on chemotherapy

    Author : Andri Papakonstantinou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Radiotherapy, endocrine therapy, chemotherapy and targeted therapy adjunct to surgery have a critical role in the management of early breast cancer for outcome improvement. Anthracycline containing chemotherapy reduces 10-year incidence of breast cancer mortality by an absolute 6. READ MORE