Search for dissertations about: "Tcf Lef"

Found 5 swedish dissertations containing the words Tcf Lef.

  2. 1. Involvement of Eicosanoid Signaling in Intestinal Epithelial Cell Survival

    Author : John Öhd; Malmö Experimentell patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; Tcf Lef; Bcl-2 family; b-catenin; 5-LO; apoptosis; cell survival; colorectal cancer; COX-2; LTD4; CysLT1 R; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Abstract : Eicosanoids are known to be involved in many different aspects of eukaryotic physiology and pathology. Notably, over the past 10 years much attention has been given to cyclooxygenase-2 (COX-2) due to its involvement in colorectal cancer. Less is known about the other major branch of arachidonic acid metabolism, namely the lipoxygenases (LO). READ MORE

  4. 2. LTD4 signalling via beta-catenin: a possible link between inflammation and cancer

    Author : Maryna Mezhybovska; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTD4; beta-catenin; colorectal cancer; CysLT1R; proliferation; inflammation;

    Abstract : The pro-inflammatory mediator LTD4 is an important component in the pathogenesis of inflammatory conditions as inflammatory bowel diseases. Patients suffering from inflammatory bowel diseases face an increased risk of intestinal cancer development. READ MORE

  5. 3. Transcriptional regulation of development in time and space

    Author : Daniel W Hagey; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Human development requires the generation of trillions of cells with myriad functions from a single cell. This requires that restriction of stem cell fate competence and proliferation are precisely temporally and spatially patterned as the embryo grows. READ MORE

  6. 4. Role of ß-catenin and Leukotriene in Colon Cancer Progression

    Author : Tavga Salim; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTD4; β-catenin; E-cadherin; GSK-3β; inflammation; colorectal cancer;

    Abstract : Abstract Colorectal cancer is the third most common cancer worldwide. Deregulation of Wnt/β-catenin signalling pathway is an early hallmark of colon cancer. Were nuclear accumulation of β-catenin is a marker of activated canonical Wnt/β-catenin signaling. One of the risk factors for development of colon cancer is inflammatory bowel disease. READ MORE

  7. 5. From membrane to nucleus : new roles and functions of SUMOylated IGF-1R and EGFR

    Author : Sylvia Packham; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell surface receptor tyrosine kinases (RTKs) role in cell signaling have been studied for decades and their role in cancer progression are undisputable. The insulin-like growth factor 1 receptor, IGF-1R, has been demonstrated to play a critical part in tumorigenesis; downregulation of the IGF-1R in tumor xenografts results in complete tumor regression. READ MORE