Search for dissertations about: "Telomeres"

Showing result 1 - 5 of 46 swedish dissertations containing the word Telomeres.

  1. 1. Analysis of Immunoglobulin Genes and Telomeres in B cell Lymphomas and Leukemias

    Author : Sarah Walsh; Richard Rosenquist; Christer Sundström; Anna Laurell; Andreas Rosenwald; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma leukemia; mantle cell lymphoma; hairy cell leukemia; lymphoplasmacytic lymphoma; immunoglobulin genes; antigen selection; telomeres; cellular origin; somatic hypermutation; Genetik; Clinical genetics; Klinisk genetik;

    Abstract : B cell lymphomas and leukemias are heterogeneous tumors with different cellular origins. Analysis of immunoglobulin (Ig) genes enables insight into the B cell progenitor, as Ig somatic hypermutation correlates with antigen-related B cell transit through the germinal center (GC). READ MORE

  2. 2. Telomeres and the brain : an investigation into the relationships of leukocyte telomere length with functional and structural attributes of the brain

    Author : Mikael Wikgren; Karl-Fredrik Norrback; Rolf Adolfsson; Göran Roos; Thomas Karlsson; Brenda Penninx; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APOE; aging; atrophy; brain; cognition; cortisol; depression; hippocampus; HPA axis; MRI; stress; telomere length; white matter hyper-intensities.;

    Abstract : Telomeres are the outermost parts of linear chromosomes. They consist of tandemly repeated non-coding short nucleotide sequences (TTAGGG in all vertebrates), in humans spanning over the last 2 to 15 kilobase pairs of the chromosome. Due to the end-replication problem, telomeres shorten with each cellular division. READ MORE

  3. 3. Chromosome dynamics and genomic instablity in neuroblastoma. Three genomic pillars: MYCN amplification, numerical and structural changes

    Author : Gisela Lundberg; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; MYCN; telomeres; chromosomal instability;

    Abstract : In this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. READ MORE

  4. 4. Molecular ecology of marine mammals

    Author : Morten Tange Olsen; Per Palsbøll; Martine Bérubé; William “Bill” Amos; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Marine mammals; molecular ecology; life history; environmental change; phenotypic plasticity; SNPs; telomeres; molekylärgenetik; Molecular Genetics;

    Abstract : Marine mammals comprise a paraphyletic group of species whose current abundance and distribution has been greatly shaped by past environmental changes and anthropogenic impacts. This thesis describes molecular ecological approaches to answer questions regarding habitat requirements, genetic differentiation, and life-history trade-offs in three species of marine mammals. READ MORE

  5. 5. Hypocortisolism in recurrent affective disorders

    Author : Martin Maripuu; Karl-Fredrik Norrback; Rolf Adolfsson; Mikael Wikgren; Marie Åsberg; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affective disorders; Bipolar disorder; Cortisol; Depression; HPA-axis; Hypercortisolism; Hypocortisolism; Lithium; Metabolic syndrome; Obesity; Quality of life; Recurrent depression; Stress; Telomeres;

    Abstract : Bipolar disorders and recurrent depressions are two common psychiatric disorders with a life time prevalence of approximately 1% and 8%, respectively. Despite treatment these patients suffer from affective symptoms up to 50% of the time, resulting in lower well-being. READ MORE