Search for dissertations about: "Teratogenicity"

Showing result 1 - 5 of 13 swedish dissertations containing the word Teratogenicity.

  1. 1. Teratogenicity as a consequence of drug-induced embryonic cardiac arrhythmia Common mechanism for almokalant, sotalol, cisapride, and phenytoin via inhibition of IKr

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna-Carin Sköld; Uppsala universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; IKr; delayed rectifying K channel; embryonic cardiac arrhythmia; teratogenicity; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; Toxicology; toxikologi;

    Abstract : During the last years, drugs that prolong the repolarisation phase of the myocardial action potential, due to inhibition of the rapid component of the delayed-rectifying potassium channel (IKr) have been in focus. In addition to arrhythmogenic potential, selective Ikr-blockers have also been shown to be embryotoxic and teratogenic in animal studies. READ MORE

  2. 2. Pluripotent Stem Cells of Embryonic Origin Applications in Developmental Toxicology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Måns Jergil; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; Toxikologi;

    Abstract : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. READ MORE

  3. 3. The informational value and usefulness of serum retinoid measurements. Studies on biological variation, including infancy and pregnancy, and influence of fasting, antiepileptic drugs and ethanol

    University dissertation from Maria Berggren Söderlund, Inst of Laboratory Medicine, Dept of Clinical Chemistry, University Hospital, SE-221 85 Lund

    Author : Maria Berggren Söderlund; Lunds universitet.; Lund University.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; vitamin A deficiency; teratogenicity; ethanol; antiepileptic drugs; caloric restriction; infant; pregnant; biological variation; 13-cis retinoic acid; all-trans retinoic acid; Vitamin A; retinol;

    Abstract : Popular Abstract in Swedish Vitamin A är nödvändigt för kroppen. Det behövs för synen och för normal utveckling av foster och celler. Vitamin A krävs t. ex. READ MORE

  4. 4. Mechanisms behind Cadmium-Induced Teratogenicity

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Estíbaliz López Fernández de Villaverde; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Cadmium; Teratogenesis; Exencephaly; Mechanisms; Toxikologi; PHARMACY Toxicology; FARMACI Toxikologi;

    Abstract : Heavy metals polluting our environment cause concern for developing organisms. Among them, cadmium with extremely slow elimination from the body, causes lower birth weight in humans but has not been classify as a human teratogen. Studies in different laboratory animals have shown that cadmium indeed is a potent teratogen. READ MORE

  5. 5. Improved environmental monitoring and assessment : Establishing links between effects of chemical pollution at different levels of biological organization in a Baltic Sea bioindicator species (Monoporeia affinis)

    University dissertation from Stockholm : Department of Environmental Science and Analytical Chemistry, Stockholm University

    Author : Martin Reutgard; Stockholms universitet.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Environmental health assessment; environmental monitoring; chemical pollution; hypoxia; bioindicators; biomarkers; teratogenicity; embryo toxicity; oxidative stress; acetylcholine esterase. Monoporeia affinis; Baltic Sea; Applied Environmental Science; tillämpad miljövetenskap;

    Abstract : A large number of chemicals enters the marine environment via atmospheric deposition, run-off, rivers and streams, industrial effluents and municipal wastewater. To understand how chemicals affect environmental health, monitoring and assessment approaches need to combine physical, chemical and biological effect parameters from different levels of biological organization. READ MORE