Search for dissertations about: "Teratogenicity"
Showing result 6 - 10 of 13 swedish dissertations containing the word Teratogenicity.
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6. Teratogenicity Involved in Experimental Diabetic Pregnancy
Abstract : Maternal diabetes is associated with increased risk of growth disturbances and congenital malformations. The malformations rate in the offspring of diabetic mothers is 2-3 fold higher compared to infants of nondiabetic mothers. READ MORE
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7. Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage
Abstract : The Antiepilptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), tri- and dimethadione (TMD and DMD) are known teratogens having a common malformation pattern in human and animal studies. This thesis was designed chiefly to test a hypothesis correlating the teratogenicity of these AEDs to episodes of pharmacologically induced embryonic arrhythmia and hypoxia-reoxygenation damage. READ MORE
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8. Role of the hERG-channel in arrhythmia and teratogenicity : studies in animal models and the human embryonic heart
Abstract : Background: Drugs that inhibit cardiac repolarization are associated with potentially life threatening side effects in the form of ventricular arrhythmias in humans. Animal studies show that this mechanism also is relevant for the embryo, and that the circulatory depression results in hypoxia with embryotoxicity in the form of malformations and death as a consequence. READ MORE
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9. Teratogenicity and in vitro fetal thymus toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin and its congeners : segregation with the Ah-locus
Abstract : .... READ MORE
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10. Assessment of Drug-Induced Cardiotoxicity during Rat Embryo Development
Abstract : The potassium ion channel (hERG/IKr) is important for normal heart function and drug-induced blockade of the channel in adult humans can lead to irregular heart rhythms (arrhythmia). The ion channel is also essential for early cardiac function in the embryo and therapeutic drugs which block this channel have been shown to cause birth defects in animal studies. READ MORE