Search for dissertations about: "Tertiary lymphoid structures"

Showing result 1 - 5 of 12 swedish dissertations containing the words Tertiary lymphoid structures.

  2. 1. Tertiary lymphoid structures in glioblastoma : Discovery, Characterization and Therapeutic Induction

    Author : Alessandra Vaccaro; Anna Dimberg; Victor Engelhard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tertiary lymphoid structures; Glioma; Glioblastoma; Immunotherapy; Immunologi; Immunology; Oncology; Onkologi;

    Abstract : Glioblastoma (GBM) is an incurable brain cancer with a median survival of less than two years from diagnosis. The tumor microenvironment plays a major role in GBM progression through sustaining immunosuppression and poor lymphocytic infiltration. READ MORE

  4. 2. Antibody-based immunotherapy of cancer : From optimization to novel approaches

    Author : Luuk van Hooren; Anna Dimberg; Eugene C. Butcher; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer immunotherapy; CD40; CTLA-4; PD-1; Gal-1; tertiary lymphoid structures;

    Abstract : Antibody immunotherapy is a successful therapeutic approach to treat cancer. The overall aim of this thesis is to investigate the mechanisms of antibody-based immunotherapies and the role of the tumor microenvironment in mediating the anti-tumor immune response, in order to aid the development of improved immunotherapies for cancer patients. READ MORE

  5. 3. Molecular characterization of the immune microenvironment in melanoma

    Author : Rita Cabrita; Melanoma Genomics; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Immune microenvironment; Tertiary lymphoid structures; Immunotherapy; Immune evasion; Methylation; Immune gene signatures;

    Abstract : .... READ MORE

  6. 4. Studies of molecular features and novel prognostic biomarkers of cutaneous melanoma

    Author : Iva Johansson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; primary cutaneous melanoma; chronic sun-damage; chronic sun-damage skin; gene expression profiling; immunohistochemistry; tertiary lymphoid structures;

    Abstract : Cutaneous malignant melanoma is a highly heterogeneous disease. Immunotherapy has revolutionized the treatment of stage IV disease and is now successfully administered as adjuvant treatment in stage III and soon in stage II. Correct identification of the patients at high risk for progressive disease who will benefit from the treatment is crucial. READ MORE

  7. 5. Vascular targeting for enhanced cancer immunotherapy

    Author : Maria Georganaki; Anna Dimberg; Sara Mangsbo; Lena Claesson-Welsh; Wolf Hervé Fridman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; tumor vasculature; endothelial activation; IDO1; ELTD1; tertiary lymphoid organ; Biologi; Biology;

    Abstract : Induced angiogenesis and chronic inflammation are major components of tumor immunosuppression. The scope of this thesis is to understand the role of the vasculature in anti-tumor immunity and thereby to improve cancer immunotherapy. READ MORE