Search for dissertations about: "Th1"

Showing result 11 - 15 of 259 swedish dissertations containing the word Th1.

  2. 11. Interplay between Pathogenic and Immune Regulatory Mechanisms in G-alpha-i2 deficient colitis

    Author : Yu-Yuan Chiu Götlind; Göteborgs universitet; []
    Keywords : IBD; G-alpha-i2 colitis; Tregs; Teffs; Th17 Th1; pathogenesis immunoregulation;

    Abstract : The two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are gastrointestinal disorders characterized by chronic and relapsing inflammation. Mice deficient in the inhibitory G protein subunit Gαi2 spontaneously develop chronic colitis and have been used as a model for IBD, with particular similarities to UC. READ MORE

  4. 12. Molecular understanding of KRAS- and BRAF-mutated colorectal cancers

    Author : Ida Lundberg; Richard Palmqvist; Maria Wikberg; Sofia Edin; Anita Sjölander; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; BRAF; KRAS; SOX2; CDX2; cancer stem cell; Th1 lymphocytes; miRNA; prognosis;

    Abstract : Colorectal cancer (CRC) is the third most commonly diagnosed malignancy in both men and women, and one of the leading causes of cancer-related deaths worldwide. One frequently mutated pathway involved in oncogenesis in CRC is the RAS/RAF/MAP kinase pathway. READ MORE

  5. 13. Co-stimulation in gut mucosal immunity. Evidence of a differential regulationof local and systemic responses

    Author : Eva Gärdby; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosal immunity; PP; cholera toxin; oral immunization; co-stimulation; Th1 Th2;

    Abstract : In recent years we have learned that co-stimulatory factors are required as second signals for optimal T cell stimulation. Most types of immune responses are, therefore, dependent on the co-stimulatory signals that are provided by infection or immunization. READ MORE

  6. 14. Functional analysis of intestinal dendritic cells

    Author : Fatemeh Ahmadi; Slemhinnans immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intestine; Dendritic cells; IRF8; IL-27; Th1 cells; Salmonella Infections; Glycoprotein 2;

    Abstract : .... READ MORE

  7. 15. Beyond Th1 and Treg : intestinal T helper cells in disease and tolerance

    Author : Rebeca Franco Cardoso; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human intestinal tract is not only one of the largest organs by surface area in our bodies but also harbors the greatest number of immune cells. These cells are crucial for maintaining tolerance towards the various food and microbial antigens and mounting protective inflammatory responses towards invading pathogens. READ MORE