Search for dissertations about: "The effects of addition a compound in drug"

Showing result 1 - 5 of 20 swedish dissertations containing the words The effects of addition a compound in drug.

  2. 1. P-glycoprotein and chiral antidepressant drugs : Pharmacokinetic, pharmacogenetic and toxicological aspects

    Author : Louise Karlsson; Fredrik C. Kugelberg; Finn Bengtsson; Johan Ahlner; Aleksander A. Mathé; Linköpings universitet; []
    Keywords : ;

    Abstract : The blood-brain barrier (BBB) is formed by the capillary endothelial cells, joined together by tight junctions, with transporter proteins. BBB acts to regulate the brain concentrations of substances including many drugs. READ MORE

  4. 2. On enhancement of bone formation using local drug delivery systems

    Author : Ali Alenezi; Ann Wennerberg; Malmö universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone formation; local drug delivery systems;

    Abstract : Introduction: Despite that many reports have confirmed the long-term clinical success rates associated with implant treatment, implant failure to achieve and maintain osseointegration still occurs in many cases. Local and sustained drug release at the bone-implant interface is one of the strategies that have been suggested to improve the osseointegration. READ MORE

  5. 3. On the role of cytochrome P450 3A4 in the metabolism of cholesterol and bile acids

    Author : Karl Bodin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Oxysterols; 4beta-hydroxycholesterol; 1beta-hydroxylated bile acids; 22hydroxylated bile acids; 3-oxo bile acids; gas chromatography-mass spectrometry;

    Abstract : The origin of 4beta-hydroxycholesterol, a major oxysterol in human circulation, has previously been unknown. In this thesis, the formation and elimination of this compound are investigated by various techniques. The biological effects of 4beta-hydroxycholesterol are also discussed. READ MORE

  6. 4. Pleiotropic effects of HMG-CoA reductase inhibitors : studies in vitro and in vivo

    Author : Cristine Skogastierna; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cardiovascular disease (CVD) is the prime cause of death in industrialized countries, resulting from the progression of atherosclerotic lesions. An increased level of plasma cholesterol, particularly within low-density lipoproteins, is a principle risk factor, but also elevated triglycerides and low levels of high-density lipoprotein cholesterol. READ MORE

  7. 5. Effects and mechanisms of actions of cyclosporin, FK506 and 15-deoxyspergualin

    Author : Anette Johansson Borg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : cyclosporin; FK506; 15-deoxyspergualin; immunosuppressive effects; transplantation;

    Abstract : Immunosuppressive drugs can be used to deal with unwanted or inappropriate immune reactions, such as the rejection of a transplanted organ. However, treatment with these drugs are often associated with serious adverse effects, and therefore less toxic immunosuppressants are desired. READ MORE