Search for dissertations about: "Theoretical Validation"

Showing result 6 - 10 of 116 swedish dissertations containing the words Theoretical Validation.

  2. 6. Simulation and analysis of radiation from runaway electrons

    Author : Mathias Hoppe; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; tokamak; runaway electrons; synthetic diagnostics; fusion; synchrotron radiation; plasma physics; bremsstrahlung;

    Abstract : Electron runaway constitutes one of the primary threats to future tokamak fusion reactors such as ITER. Successful prevention and mitigation of runaways relies on the development of theoretical models which accurately describe the dynamics of runaway electrons, and these models must in turn be validated in experiments. READ MORE

  4. 7. Modeling and simulation of intrinsically disordered proteins

    Author : Joao Henriques; Beräkningskemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Intrinsically disordered proteins; Coarse-grained models; Atomistic models; Metropolis Monte Carlo simulations; Molecular dynamics simulations; Sampling; Conformational analysis; Charge regulation; Surface adsorption;

    Abstract : This work is primarily about the development, validation and application of computer simulation models for intrinsically disordered proteins, both in solution and in the presence of uniformly charged, ideal surfaces. The models in question are either coarse-grained or atomistic in nature, and their applications are dependent on the specific purpose of each study. READ MORE

  5. 8. Computational Modelling of Ligand Complexes with G-Protein Coupled Receptors, Ion Channels and Enzymes

    Author : Lars Boukharta; Johan Åqvist; Christopher A. Reynolds; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; computer simulations; molecular dynamics; ligand binding; free energy perturbation; linear interaction energy; binding free energy; homology modelling; structure prediction; alanine scanning; site-directed mutagenesis; hERG; GPCR; neuropeptide Y; HIV-1 reverse transcriptase; integron integrase; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Accurate predictions of binding free energies from computer simulations are an invaluable resource for understanding biochemical processes and drug action. The primary aim of the work described in the thesis was to predict and understand ligand binding to several proteins of major pharmaceutical importance using computational methods. READ MORE

  6. 9. Saving Energy in Construction Machinery using Displacement Control Hydraulics : Concept Realization and Validation

    Author : Kim Heybroek; Jan-Ove Palmberg; Jochen Pohl; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Fluid mechanics; Strömningsmekanik;

    Abstract : In the sector of mobile hydraulics, valve controlled systems are predominant. In these systems the load force and speed are adjusted by control valves. In machines where multiple drives are used in parallel at extremely varying loads the energy efficiency of such systems is often compromised over large working regions. READ MORE

  7. 10. On the subjective–objective distinction for measures of memory and cognition : Theoretical and methodological issues in questionnaire development and validation

    Author : Peter Vestergren; Widar Henriksson; Christina Wikström; Michael Rönnlund; Björn Lyxell; Umeå universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; cognitive dysfunction; measurement; memory complaints; self report; subjective memory; subjective–objective; Other social sciences; Övrig samhällsvetenskap; didactics of educational measurement; beteendevetenskapliga mätningar;

    Abstract : The aim of this thesis was to develop a questionnaire for cognitive functioning, which could possibly be used as a screening instrument for early signs of dementia in the future. The introduction discusses the often made distinction between subjective and objective measures. READ MORE