Search for dissertations about: "Theory Papers of drug"

Showing result 1 - 5 of 24 swedish dissertations containing the words Theory Papers of drug.

  2. 1. On the Optimisation and Regulation of Clinical Trials

    Author : Sebastian Jobjörnsson; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; decision theory; Bayesian statistics; optimal stopping.; clinical trials; subgroup analysis; drug regulation;

    Abstract : The basic premise of this thesis is that Bayesian Decision Theory (BDT) can and should be used to solve clinical trial design problems. While the flexibility of the framework allows for accommodating a great variety of situations, it also requires an explicit consideration of the gains and costs associated with the trial. READ MORE

  4. 2. Expressions of context : Studies of schools, families, and health risk behaviours

    Author : Gabriella Olsson; Johan Fritzell; Bitte Modin; Michaela Benzeval; Stockholms universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Sociology; sociologi;

    Abstract : This thesis explores the health behaviours of young people. The main focus is on risk behaviours, i.e. those which may have adverse consequences for health. READ MORE

  5. 3. Microarray Analysis of mRNA Decay Assays and Prediction of Drug Target Conservation

    Author : Alexandra Jauhiainen; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microarray analysis; mRNA decay; evolutionary conservation; ecotoxicology; environmental risk assessments; ecotoxicology;

    Abstract : This thesis contains two papers concerning (I) the evolutionary conservation of drug targets and its potential use in environmental risk assessments and (II) mRNA degradation as a control mechanism during osmotic stress in the yeast S. cerevisiae. Environmental risk assessments are needed for the approval of new pharmaceutical compounds. READ MORE

  6. 4. Modelling of drug-effect on time-varying biomarkers

    Author : Felix Held; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cortisol; TNFα; hierarchical modelling; turnover model; pharmacokinetic pharmacodynamic modelling; cortisol TNFα hierarchical modelling turnover model pharmacokinetic pharmacodynamic modelling;

    Abstract : Model-based quantification of drug effect is an efficient tool during pre-clinical and clinical phases of drug trials. Mathematical modelling can lead to improved understanding of the underlying biological mechanisms, help in finding shortcomings of experimental design and suggest improvements, or be an effective tool in simulation-based analyses. READ MORE

  7. 5. Statistical analysis of gene expression data

    Author : Erik Kristiansson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; gene expression; DNA microarrays; linear models; empirical Bayes; quality control; gene regulation; categorical data analysis; logistic regression; heavy metal stress; ecotoxicology; gene expression;

    Abstract : Microarray technology has become one of the most important tools for genome-wide mRNA measurements. The technique has been successfully applied to many areas in modern biology including cancer research, identification of drug targets, and categorization of genes involved in the cell cycle. READ MORE