Search for dissertations about: "Thermodynamic stability"

Showing result 16 - 20 of 132 swedish dissertations containing the words Thermodynamic stability.

  2. 16. Nucleic Acids as Drugs and Drug Targets With Focus on Anticancer Active Platinum Complexes and Small Interfering RNAs

    Author : Hanna Hedman; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; siRNA; thermodynamic stability; mass spectrometry; MALDI-MS; chemical probing; luciferase assay;

    Abstract : To ensure that patients receive a safe and effective treatment, it is important to understand how drugs interact with and affect molecules within a cell. Here, evaluation of platinum based drugs and their ability to interfere with nucleic acid functions is presented. READ MORE

  4. 17. On the stability of proteins from hyperthermophiles : a structural and thermodynamic study

    Author : Stefan Knapp; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Protein stability; hyperthermophiles; X-ray crystallography; glutamate dehydrogenase; Sso7d.;

    Abstract : In this study the structural and thermodynamic basis of the thermal stability of proteins has been studied using proteins from hyperthermophilic organisms as model systems. A new type of chaperonin (TF55) has been isolated from the hyperthermophilic archaeon Sulfolobus solfataricus consisting of two different subunits named TF55-alpha and TF55-beta. READ MORE

  5. 18. Structure determination and thermodynamic stabilization of an engineered protein-protein complex

    Author : Elisabet Wahlberg; Per-Åke Nygren; Bengt-Harald Jonsson; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; protein structure; coupled folding; NMR spectroscopy; protein stability; protein-protein interactions; binding thermodynamics; isothermal titration calorimetry; protein engineering; Structural biochemistry; Strukturbiokemi;

    Abstract : The interaction between two 6 kDa proteins has been investigated. The studied complex of micromolar affinity (Kd) consists of the Z domain derived from staphylococcal protein A and the related protein ZSPA-1, belonging to a group of binding proteins denoted affibody molecules generated via combinatorial engineering of the Z domain. READ MORE

  6. 19. Thermodynamic Toolkit for Chemical Recycling to Monomer

    Author : Linnea Cederholm; Karin Odelius; Minna Hakkarainen; Peter Olsen; Louis Pitet; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; chemical recycling to monomer; polymerization thermodynamics; ring-opening polymerization; solvent effect; polyester; polycarbonate; copolymer; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Abstract : The design of polymeric materials for a circular economy is, to a largeextent, a challenge of thermodynamics. The work presented in this thesishas explored the thermodynamic features of ring-opening polymerizationand ring-closing depolymerization, to develop polymeric materials andrecycling strategies for chemical recycling to monomer. READ MORE

  7. 20. Thermodynamic modelling of carbides in multicomponent systems : theoretical and experimental approach

    Author : Andreas Markström; Bo Sundman; José Garcia; KTH; []
    Keywords : ;

    Abstract : This thesis concerns thermodynamic modeling of carbides in multicomponent systems. Focus has been made on systems interesting for cemented carbide production but the results are also useful for many other application were the material consist of different carbides, for example tool steels/high speed steels. READ MORE