Search for dissertations about: "Thiazolidinediones"

Showing result 1 - 5 of 11 swedish dissertations containing the word Thiazolidinediones.

  1. 1. Regulation of intracellular signaling events that modulate insulin action

    University dissertation from Göteborg

    Author : Silvia Gogg; Göteborgs universitet.; Gothenburg University.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin; insulin resistance; EGF; Gab 1; insulin receptor substrate; PI3-kinase; Thiazolidinediones; PPARã; insulin signaling; glucose transport; adipose tissue; â-cell.;

    Abstract : Insulin regulates several mechanisms of fundamental importance to the body involving glucose, fat andprotein metabolism. Insulin resistance in skeletal muscle, liver and adipose tissue promotes an increaseddemand for insulin secretion. READ MORE

  2. 2. Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Mozhgan Dorkhan; Lunds universitet.; Lund University.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; insulin secretion; glucagon test; insulin resistance; insulin glargine; insulin tolerance test; thiazolidinediones; natriuretic peptides; adiponectin; thyroid associated ophthalmopathy; proinsulin;

    Abstract : Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. READ MORE

  3. 3. Post-transplantation Hypercholesterolaemia

    University dissertation from Malmö University Hospital, Wallenberg Lab. 2nd floor, 205 02 Malmö, Sweden

    Author : Osama Al Rayyes; Lunds universitet.; Lund University.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thiazolidinediones; transplantation; low density lipoprotein; insulin; indomethacin; hydrocortisone; fluvastatin; flufenamic acid; Cholesterol; cyclosporine; troglitazone.; Immunology; serology; Immunologi; serologi;

    Abstract : The multidrug regimen, cyclosporine, corticosteroids, and azathioprine, is used in transplantation centres to prevent organ rejection. Several clinical studies have shown that cyclosporine and corticosteroids to cause increases in low density lipoprotein (LDL)-cholesterol, with subsequent development of atherosclerosis. READ MORE

  4. 4. Molecular characterization of insulin resistance in the adipose tissue and the effects of thiazolidinediones

    University dissertation from Malmö University Hospital, Wallenberg Lab. 2nd floor, 205 02 Malmö, Sweden

    Author : Ann Hammarstedt; Göteborgs universitet.; Gothenburg University.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IRS-1; PGC-1; adiponectin; insulin resistance; TZD;

    Abstract : Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many contries. Insulin resistance plays a central role in the pathogenesis of Type 2 diabetes and can be present for a decade or more before onset of the disease. READ MORE

  5. 5. Mechanisms regulating metabolic and mitogenic events in skeletal muscle : implications for insulin resistance and exercise

    University dissertation from Stockholm : Karolinska Institutet, Department of Surgical Science

    Author : Jeffrey W. Ryder; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; skeletal muscle; glucose transport; GLUT4; hypoxia; exercise; Type II diabetes; MAPK; PPAR[gamma] thiazolidinediones;

    Abstract : Reduced glucose transport in skeletal muscle is a hallmark feature of Type II diabetes. Numerous mechanisms acutely or chronically regulate skeletal muscle glucose transport. The role of GLUT4, mitogen-activated protein kinases (MAPK), and peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) were examined in skeletal muscle. READ MORE