Search for dissertations about: "Thioredoxin reductase"

Showing result 1 - 5 of 57 swedish dissertations containing the words Thioredoxin reductase.

  2. 1. Selenium in mammalian thioredoxin reductase

    Author : Liangwei Zhong; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Thioredoxin reductase (TrxR) is a major enzyme in regulating intracellular redox status. The enzyme from several mammalian tissues has been purified, showing higher molecular weight and a much broader substrate specificity than E. coli TrxR, but the structural basis of these properties remained unknown. READ MORE

  4. 2. Exploring thioredoxin reductase as an anticancer drug target

    Author : Stefanie Prast-Nielsen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mammalian thioredoxin reductase (TrxR; EC 1.8.1.9) is a homodimeric NADPH-dependent selenium-containing flavoenzyme with disulfide oxidoreductase activity. READ MORE

  5. 3. Thioredoxin reductase and selenium in carcinogenesis and multidrug resistance

    Author : Linda Björkhem Bergman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The thioredoxin system, comprising thioredoxin, thioredoxin reductase (TrxR) and NADPH, is a redox system of great importance in the defence against oxidative stress and is involved in the regulation of several cellular processes, such as apoptosis and cell proliferation. In addition, TrxR is a selenoenzyme and is a key enzyme in selenium metabolism. READ MORE

  6. 4. The chloroplast lumen : New insights into thiol redox regulation and functions of lumenal proteins

    Author : Michael Hall; Wolfgang Schröder; Bob B. Buchanan; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Photosynthesis; thylakoid lumen; thioredoxin; pentapeptide repeat; proteomics; Biochemistry; biokemi;

    Abstract : In higher plants oxygenic photosynthesis primarily takes place in the chloroplasts of leaves. Within the chloroplasts is an intricate membrane system, the thylakoid membrane, which is the site of light harvesting and photosynthetic electron transport. READ MORE

  7. 5. Elucidation of thioredoxin reductase 1 as an anticancer drug target

    Author : William C Stafford; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer constantly finds ways to survive, so we must find new ways to stop it. A major attribute of cancer cells is increased oxidative stress, occurring in the form of reactive oxygen species (ROS). Basal ROS generation commonly occurs in all types of cells and is essential for normal cellular growth and function. READ MORE