Advanced search

Found 4 swedish dissertations matching the above criteria.

2. 1. The Immune Response to One-Lung Ventilation : Clinical and Experimental Studies

   Author : Thomas Schilling; Göran Hedenstierna; Hans Hedenström; Thomas Hachenberg; Sven-Erik Ricksten; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; One-lung ventilation; open thoracic surgery; ventilation-induced lung injury; alveolar immune response; bronchoalveolar lavage; propofol; desflurane; cytokines; animal model; mRNA; RT-PCR; Medical laboratory science; Medicinsk laboratorievetenskap; anestesiologi; Anaesthesiology;

   Abstract : One-lung ventilation (OLV) as an established procedure during thoracic surgery may be injurious in terms of increased mechanical stress characterised by alveolar cell stretch and overdistension, increased cyclic tidal recruitment of alveolar units, compression of alveolar vessels and increased pulmonary vascular resistance. This may result in ventilation-induced lung injury with pro-inflammatory cytokine production, leukocyte recruitment and neutrophil-dependent tissue destruction. READ MORE

4. 2. Gas exchange impairment in patients undergoing cardiac surgery : with reference to ventilation-perfusion relationships, thoracic intravascular and extravascular fluid volumes, pulmonary morphology and mechanical ventilation in the prone position

   Author : Thomas Hachenberg; Uppsala universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : .... READ MORE

5. 3. Remote Ischemic Preconditioning and its Effects on the Respiratory System

   Author : Astrid Bergmann; Anders Larsson; Göran Hedenstierna; Thomas Hachenberg; Ola Winsö; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; one-lung ventilation; ventilation-induced lung injury; alveolar immune response; remote ischemic preconditioning; exhaled nitric oxide; animal model; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

   Abstract : Mechanical ventilation in itself can lead to pulmonary damage, and one-lung ventilation (OLV), necessary for thoracic surgery, accentuates this injury. Remote ischemic preconditioning (RIP) is a potential tool to reduce lung injury after mechanical ventilation, including OLV.  However, current data on pulmonary RIP-effects are contradictory. READ MORE

6. 4. Pathophysiological and Histomorphological Effects of One-Lung Ventilation in the Porcine Lung

   Author : Alf Kozian; Göran Hedenstierna; Thomas Hachenberg; Filip Freden; Sten Walther; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alveolar Recruitment Manoeuvre; One-Lung Ventilation; Lung Protective Ventilation; Tidal Volume; Computed Tomography; Tidal Recruitment; Animal Model; Open Thoracic Surgery; Ventilation Perfusion Distribution; Single Photon Emission Computed Tomography; Diffuse Alveolar Damage; Medical laboratory science; Medicinsk laboratorievetenskap; Anestesiologi; Anaesthesiology;

   Abstract : Thoracic surgical procedures require partial or complete airway separation and the opportunity to exclude one lung from ventilation (one-lung ventilation, OLV). OLV is commonly associated with profound pathophysiological changes that may affect the postoperative outcome. READ MORE