Search for dissertations about: "Thomas Moritz"

Showing result 1 - 5 of 6 swedish dissertations containing the words Thomas Moritz.

  2. 1. Metabolomics studies of ALS : a multivariate search for clues about a devastating disease

    Author : Anna Wuolikainen; Peter M Andersen; Henrik Antti; Stefan L Marklund; Thomas Moritz; Thomas Hankemeier; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyotrophic lateral sclerosis ALS ; motor neuron disease; Lou Gehrig’s disease; human disease; CSF; biomarkers; metabolomics; metabonomics; chemometrics; design of experiments; multivariate analysis.; Neurology; Neurologi; Neurology; neurologi;

    Abstract : Amyotrophic lateral sclerosis (ALS), also known as Charcot’s disease, motor neuron disease (MND) and Lou Gehrig’s disease, is a deadly, adult-onset neurodegenerative disorder characterized by progressive loss of upper and lower motor neurons, resulting in evolving paresis of the linked muscles. ALS is defined by classical features of the disease, but may present as a wide spectrum of phenotypes. READ MORE

  4. 2. Managing and Exploring Large Data Sets Generated by Liquid Separation - Mass Spectrometry

    Author : Daniel Bäckström; Per Sjöberg; Rolf Danielsson; Thomas Moritz; Uppsala universitet; []
    Keywords : Analytical chemistry; liquid chromatography; capillary electrophoresis; capillary electrochromatography; mass spectrometry; electro spray ionization; chemometrics; multivariate data analysis; peptide; biomarkers; fingerprints; PCA; alignment; data compression; ANOVA; target correlation; data management; Analytisk kemi;

    Abstract : A trend in natural science and especially in analytical chemistry is the increasing need for analysis of a large number of complex samples with low analyte concentrations. Biological samples (urine, blood, plasma, cerebral spinal fluid, tissue etc. READ MORE

  5. 3. Selectivity in NMR and LC-MS Metabolomics : The Importance of Sample Preparation and Separation, and how to Measure Selectivity in LC-MS Metabolomics

    Author : Albert Elmsjö; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; NMR; LC-MS; HILIC; UHPLC; Q-ToF; selectivity; co-feature ratio; method evaluation; data evaluation; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : Until now, most metabolomics protocols have been optimized towards high sample throughput and high metabolite coverage, parameters considered to be highly important for identifying influenced biological pathways and to generate as many potential biomarkers as possible. From an analytical point of view this can be troubling, as neither sample throughput nor the number of signals relates to actual quality of the detected signals/metabolites. READ MORE

  6. 4. Metabolic variation in autoimmune diseases

    Author : Rasmus Kirkegaard Madsen; Johan Trygg; Thomas Moritz; Torbjörn Lundstedt; Matej Oresic; Umeå universitet; []
    Keywords : Rheumatoid Arthritis; Diabetes Mellitus type 1; Metabolic Profiling; Metabolomics; Chemometrics; Multivariate Data Analysis; Mass Spectrometry; biologisk kemi; biological chemistry;

    Abstract : The human being and other animals contain immensely complex biochemical processes that govern their function on a cellular level. It is estimated that several thousand small molecules (metabolites) are produced by various biochemical pathways in humans. READ MORE

  7. 5. Development of analytical methods for the determination of the small molecule component of complex biological systems

    Author : Kristian Pirttilä; Mikael Hedeland; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; metabolomics; data processing; peak characterization; algorithm; multivariate data analysis; chromatography; sequential columns; HILIC; RPLC; liquid chromatography; mass spectrometry; LC; MS; noise-induced hearing loss; NIHL; guinea pig; perilymph; method development; validation; R; C ; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : The research field of untargeted metabolomics aims to determine the relative abundance of all small metabolites in a biological system in order to find biomarkers or make biological inference with regards to the internal or external stimuli. This is no trivial aim, as the small metabolites are both vast in numbers and extremely diverse in their chemical properties. READ MORE