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Showing result 1 - 5 of 14 swedish dissertations matching the above criteria.

2. 1. Adoptive T Cell Therapy of Viral Infection and Cancer : Ex vivo Expansion of Cytomegalovirus- and Prostate Antigen-specific T Cells

   Author : Björn Carlsson; Magnus Essand; Thomas Tötterman; Malcolm Brenner; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Immunotherapy; Adoptive T cell therapy; Dendritic cell; T cell; Tetramer; Cytomegalovirus; Transplantation; pp65; Prostate cancer; TARP; Prostate antigens; Immunologi; Immunology; Immunologi;

   Abstract : The main focus of my thesis has been to develop protocols for generating antigen-specific cytotoxic T lymphocytes (CTLs) and T helper cells (TH) for adoptive transfer to treat cytomegalovirus (CMV) disease and prostate cancer. CMV viremia is a severe complication in immunocompromised stem cell transplanted patients. READ MORE

4. 2. TARP Promoter-Based Prostate Cancer Gene Therapy : From Development to Application

   Author : Wing-Shing Cheng; Magnus Essand; Thomas H. Tötterman; Cecilia Lundberg; Uppsala universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Genetic engineering; TARP; PPT; TSTA; promoter; gene regulation; prostate specificity; hormone- independent; adenovirus; prostate cancer; gene therapy; conditionally replicating adenovirus; Genteknik; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

   Abstract : Prostate cancer is one leading cause of cancer-related death among men in Western countries. The standard therapies for localized prostate cancer include radical prostatectomy and radiation therapy. Such measures are relatively effective in the short term, but many patients ultimately relapse. READ MORE

5. 3. Adenovirus-mediated Gene Therapy of Prostate Cancer

   Author : Angelika Danielsson; Mangus Essand; Thomas H. Tötterman; Gunnel Hallden; Uppsala universitet; []
   Keywords : adenovirus; adenoviral vector; oncolytic virus; gene therapy; prostate cancer; PEGylation; HDAC inhibitor; whole blood model; whole blood neutralization assay; MEDICINE; MEDICIN; Klinisk immunologi; Clinical Immunology; Molekylär genetik; Molecular Genetics;

   Abstract : Adenovirus-mediated gene therapy is a potential complement to standard cancer treatments. Advantages are that vectors can be used to target tumors and that replicating viruses lead to increased therapeutic dosage. READ MORE

6. 4. Adenovirus-mediated CD40 Ligand Immunotherapy of Prostate and Bladder Cancer

   Author : Helena Dzojic; Magnus Essand; Thomas H Tötterman; Aristides Eliopoulos; Uppsala universitet; []
   Keywords : Medicine; immunotherapy; gene therapy; prostate cancer; bladder cancer; adenoviral vector; CD40 ligand; promoter; PPT; TSTA; depsipeptide FK228; TRAMP-C2; Medicin;

   Abstract : Cancer immunotherapy aims at reversing the immunosuppressive tumor environment and enhancing anti-tumor immunity. This thesis comprises studies on murine models for prostate (TRAMP-C2) and bladder (MB49) cancer with the aim to explore if the introduction of an adenoviral vector expressing CD40 ligand (AdCD40L) can induce anti-tumor immune responses. READ MORE

7. 5. Generation of Therapeutic T Cells for Prostate Cancer

   Author : Ole Forsberg; Magnus Essand; Thomas Tötterman; Gustav Gaudernack; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; T cells; dendritic cells; peptides; cytomegalovirus; adenovirus; immunotherapy; Clinical immunology; Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

   Abstract : The work presented herein focuses on the activation of the adaptive immune system in order to develop T cell-based immunotherapy for viral infections and cancer. The main goal was to identify and activate viral or tumoral antigen-specific T cells by using different identification, isolation and stimulation techniques. READ MORE