Search for dissertations about: "Thrombin inhibitor"

Showing result 21 - 25 of 47 swedish dissertations containing the words Thrombin inhibitor.

2. 21. Thrombosis in Children

   Author : Olof Rask; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Child; Estradiol; Heart Defects; Congenital; Hemostasis; Protein C Inhibitor; Risk factors; Thrombophilia; Thromboembolism; Autoantibodies; Adolescent;

   Abstract : Aims: The general objective was to further elucidate thromboembolic disease in children and thereby help improve the care of these patients. More specific aims were as follows: to determine what children are affected by thrombosis; to discern any gender or age differences related to thrombosis; to identify prothrombotic risk factors; to ascertain whether autoantibodies against coagulation proteins constitute a risk factor for childhood thrombosis; to study girls receiving estrogen treatment with regard to induced hemostatic changes and efficacy of the therapy; to investigate long-term effects on the hemostatic system in children subjected to heart surgery. READ MORE

4. 22. Development of Methods for Measuring Protein C Inhibitor and Antithrombin: Use of Monoclonal Antibodies against the Reactive Center Loop-Inserted Forms of the Serpins

   Author : Margareta Kjellberg; Malmö Klinisk kemi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; monoclonal antibody; latent antithrombin; immunoassay; cleaved PCI; cleaved antithrombin; Antithrombin; APC-PCI complex;

   Abstract : Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. READ MORE

5. 23. Design and synthesis of inhibitors that target the serine protease thrombin, the malarial aspartyl proteases plasmepsin I and II, and the hepatitis C virus NS3 serine protease

   Author : Per-Ola Johansson; Mats Larhed; Linköpings universitet; []
   Keywords : NATURAL SCIENCES; NATURVETENSKAP;

   Abstract : This thesis addresses the design, synthesis, and structure-activity relationships of protease inhibitors that target the serine protease thrombin, the malarial aspartic proteases plasmepsin I and II, and the hepatitis C virus (HCV) NS3 serine protease. Furthermore, the backgrounds of each of the three types of diseases in question are discussed in detail, and consideration is given as to why it is assumed that inhibition of the mentioned proteases will help prevent or cure cardiovascular diseases, malaria, and hepatitis C. READ MORE

6. 24. Mechanisms of thrombosis and restenosis after vascular injury

   Author : Carl Magnus Wahlgren; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Restenosis; neointimal hyperplasia; thrombin inhibition; angioplasty; PTA; outcome analysis; coagulation; inflammation; CRP; thioredoxin; oxidative stres;

   Abstract : Atherosclerosis is the underlying cause of about 50% of all deaths in the western world. Peripheral vascular disease commonly affects the arteries supplying the leg and is mostly caused by atherosclerosis. READ MORE

7. 25. Studies on fibrin gel structure

   Author : Kamaran T Fatah; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Fibrinogen; fibrin gel structure; plasma; thrombin; fibrinolysis; fibrin gel; zinc ion; plasminogen; crosslinking; acetylsalicylic acid; atherosclerosis; coronary heart disease;

   Abstract : Fibrin gel formation is the final result of interaction between multiple plasma proteins; as a result of activation, fibrinogen is converted to fibrin and crosslinking of fibrin occurs by activated factor XIII, which stabilises the formed clot. Fibrin gel networks were studied in purified fibrinogen systems and in plasma samples from patients with cardiovascular complications and healthy individuals, using light-scattering, turbidity, liquid permeation and confocal 3D microscopy techniques. READ MORE