Search for dissertations about: "Thymic epithelial cells"

Showing result 11 - 15 of 17 swedish dissertations containing the words Thymic epithelial cells.

  2. 11. Beyond conventional care : developing novel therapeutic approaches to combat arthritis

    Author : Zhongwei Xu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) is an autoimmune disorder without a definitive cure. Although RA is driven by systemic autoimmunity, its most pronounced manifestation is organspecific inflammation, particularly synovitis in joints. Persistent synovitis results in progressive joint damage and deformity, ultimately compromising joint function. READ MORE

  4. 12. Targeting viral induced TSLP - an airway treatment opportunity

    Author : Angelica Brandelius; Respiratorisk immunofarmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Respiratory viral infections cause exacerbations of asthma and COPD that cannot be effectively treated today. Thymic Stromal Lymphopoietin (TSLP) is an upstream epithelial cytokine linking the innate and adaptive immune system. Viral stimuli induce epithelial overexpression of TSLP in asthma and COPD. READ MORE

  5. 13. Immunological, vascular and metabolic actions of androgens

    Author : Marta Lantero Rodriguez; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; androgens; androgen receptor; immune system; atherosclerosis; abdominal aortic aneurysm; brown fat; mice;

    Abstract : Men have higher prevalence of cardiovascular disease (CVD) but lower risk of autoimmune disorders than women. The actions of sex steroids may be involved in the sexual dimorphism of these diseases. Although testosterone, the main androgen, seems to protect against autoimmunity, its role in CVD is contradictory and disease-dependent. READ MORE

  6. 14. Unveiling the protective mechanisms of NOX2-derived ROS against autoimmune diseases

    Author : Huqiao Luo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), pose a significant burden on society, affecting a considerable portion of the global population. Both SLE and RA are known to have a strong genetic component, with shared genetic predispositions such as neutrophil cytosolic factor 1 (NCF1), which encodes for a subunit of NADPH oxidase 2 (NOX2) complex. READ MORE

  7. 15. Roles of Androgens in Cardiovascular Physiology and Pathophysiology

    Author : Elin Svedlund Eriksson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; androgens; androgen receptor; atherosclerosis; myocardial infarction; immune system; SARMs; male mice;

    Abstract : ABSTRACT Atherosclerosis is the major underlying cause of cardiovascular disease, such as myocardial infarction (MI) and stroke, and these conditions are the leading causes of death both in Sweden and globally. The immune system is involved in the pathogenesis of atherosclerosis as well as post-MI cardiac injury. READ MORE