Search for dissertations about: "Thymidine: metabolism"

Showing result 1 - 5 of 9 swedish dissertations containing the words Thymidine: metabolism.

  2. 1. Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei

    Author : Munender Vodnala; Anders Hofer; Arne Holmgren; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Trypanosoma brucei; adenosine kinase; thymidine kinase; methylthioadenosine phosphorylase; mouser ribonucleotide reductase; E. coli ribonucleotide reductase; RNR; Ara-A; F-Ara-A; dNTP; NTP; doexynucleotide metabolism; nucleosides; nucleoside kinases; allosteric regulation; biologisk kemi; biological chemistry;

    Abstract : Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs.T. READ MORE

  4. 2. Studies of nuclear encoded mitochondrial proteins in metabolism

    Author : Qian Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mitochondrial function is vital for human health. Inherited genetic disease can cause mitochondrial DNA (mtDNA) deficiency, disorders with generally poor prognosis. The majority of the genesinvolved in keeping a normal mitochondrial function are nuclear encoded. READ MORE

  5. 3. Studies on the regulation of hepatic and intestinal lipid metabolism

    Author : Kristina Kannisto; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Disturbances in the lipid homeostasis can result in a wide variety of different diseases and symptoms. This thesis is focused on the regulation of cholesterol metabolism and its relation to atherosclerosis development, and the effect of mitochondrial (mt)DNA depletion on hepatic β-oxidation of fatty acids. READ MORE

  6. 4. The metabolism of HIV RT inhibitors : biochemical and clinical studies

    Author : Bengt Jacobsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : HIV infection is currently treated with a combination of nucleoside analogues and protease inhibitors. Nucleoside analogues inhibit HIV-1 reversed transcriptase (RT), a vital enzyme in the life cycle of HIV. Nucleoside analogues are phophorylated by host-cell enzymes to their respective triphosphate. READ MORE

  7. 5. Targets and strategies for drug development against human African sleeping sickness

    Author : Farahnaz Ranjbarian; Anders Hofer; Staffan G. Svärd; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T. brucei thymidine kinase; T. brucei methylthioadenosine phosphorylase; FANA-A purine nucleoside analogues; essential oils;

    Abstract : Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. READ MORE