Search for dissertations about: "Tissue Plasminogen Activator blood"
Showing result 1 - 5 of 35 swedish dissertations containing the words Tissue Plasminogen Activator blood.
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1. Genetic variation at the human tissue-type plasminogen activator locus
Abstract : Tissue-type plasminogen activator (tPA) is the key initiator of intravascular fibrinolysis. Family studies suggest that tPA release is regulated by hereditary factors. READ MORE
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2. Blood Pressure Elevation - Impact on Cardiovascular Structure and Endogenous Fibrinolysis
Abstract : Blood pressure elevation is a major risk factor for cardiovascular events and the risk increases in a dose-dependant manner. It is of importance to identify subjects prone to develop hypertension and adverse cardiovascular remodeling in order to start treatment timely. READ MORE
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3. Experimental studies of the regulations of synthesis and release of tissue-type plasminogen activator from vascular endothelium
Abstract : The fibrinolytic system has several important functions and one crucial function is the prevention and removal of fibrin deposits in blood vessels. Tissue-type plasminogen activator (t-PA) plays a key role in this process, and in vitro data suggest that an acute release of t-PA is induced as a thromboprotective response whenever clotting mechanisms are initiated. READ MORE
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4. On the Regulation of the Serine Protease t-PA and its Inhibitor PAI-1 in the Brain
Abstract : The serine protease tissue-type plasminogen activator (t-PA) is the main fibrinolytic enzyme in the vascular system, and thus plays a critical role in the dissolution of thrombi. In recent years, researchers have focused on its role within the brain, where t-PA has been shown to participate in a number of physiological and pathophysiological processes, including various aspects of synaptic plasticity and neurodegeneration. READ MORE
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5. Local regulation of the endogenous fibrinolytic system in man
Abstract : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (tPA). The endothelium synthesises and stores tPA and regulated release of the enzyme is an important mechanism for removal of fibrin from blood vessels. Plasminogen activator inhibitor type-1 (PAI-1) is the main inhibitor of tPA. READ MORE