Search for dissertations about: "Torbjörn Gräslund"

Showing result 1 - 5 of 14 swedish dissertations containing the words Torbjörn Gräslund.

  2. 1. Protein Engineering by Directed Evolution and Rational Design

    Author : Torbjörn Gräslund; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; ion-exchange chromatography; subtilisin; Klenow DNA polymerase; Taq DNA polymerase; directed evolution; rational design; charge engineering; phosphonylating inhibitor; phage display; circular dichroism; protein A; Bioengineering; Bioteknik;

    Abstract : .... READ MORE

  4. 2. Targeting HER2-expressing tumors with potent drug conjugates and fusion toxins based on scaffold proteins

    Author : Haozhong Ding; Torbjörn Gräslund; Stefan Ståhl; Harald Kolmar; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Targeted therapy; affibody molecules; ADAPT molecules; AffiDC; fusion toxins; HER2; Biotechnology; Bioteknologi;

    Abstract : Targeted therapy is an emerging treatment for a variety of cancers. Small- sized scaffold proteins are an alternative to conventional antibody-based targeting molecules. READ MORE

  5. 3. Tools in biocatalysis : enzyme immobilisation on silica and synthesis of enantiopure amines

    Author : Karim Engelmark Cassimjee; Per Berglund; Torkel Berglund; Torbjörn Gräslund; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This thesis presents two techniques in the field of biocatalysis: An enzyme immobilisation method based on the His6-tag for attachment on modified silica oxide beads, and it’s employment in aqueous and organic medium for synthesis applications. The method functions as a one step extraction and immobilisation protocol. READ MORE

  6. 4. Biochemical and structural characterization of two thermostable carbohydrate-active enzymes with potential in biotechnological applications

    Author : Noor Hassan; Christina Divne; Torbjörn Gräslund; Henrik Hansson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  7. 5. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting

    Author : Camilla Hofström; Torbjörn Gräslund; Serge Muyldermans; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecules; affinity proteins; radionuclide molecular imaging; intracellular targeting; EGFR; HER2; IGF-1R; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Abstract : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. READ MORE