Search for dissertations about: "Toxicity testing"

Showing result 1 - 5 of 68 swedish dissertations containing the words Toxicity testing.

2. 1. Towards new computational tools for predicting toxicity

   Author : Swapnil Chavan; Ian Nicholls; Scott Boyer; Linnéuniversitetet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Acute toxicity; chronic toxicity; hERG; k-NN; LD50; LOEL; Munro database; QSAR; read-across; toxicity; Medicinsk kemi; Medical Chemistry;

   Abstract : The toxicological screening of the numerous chemicals that we are exposed to requires significant cost and the use of animals. Accordingly, more efficient methods for the evaluation of toxicity are required to reduce cost and the number of animals used. READ MORE

4. 2. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications

   Author : Caroline Haglund; Elin Lindhagen; Rolf Larsson; Anna Åleskog; Sigurd Vitols; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticancer drugs; In vitro assays; Toxicity testing; Haematological toxicity; Primary tumour cells; Species difference; Clinical pharmacology; Klinisk farmakologi; Clinical Pharmacology; Klinisk farmakologi;

   Abstract : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. READ MORE

5. 3. In vitro toxicity testing using human pluripotent stem cell derivatives

   Author : Gustav Holmgren; Anders Lindahl; Jane Synnergren; Peter Sartipy; Chris Denning; Sahlgrenska Academy at University of Gothenburg; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicity testing; human pluripotent stem cells; cardiomyocytes; hepatocytes; microarray; quantitative proteomics; bioinformatics; transcriptomics; microRNA; Medical sciences; Medicin; Bioinformatik; Bioinformatics;

   Abstract : .... READ MORE

6. 4. Aquatic primary producers in toxicity testing : emphasis on the macroalga Ceramium strictum

   Author : Britta Eklund; Murray T. Brown; Stockholms universitet; []
   Keywords : marin ekologi; Marine Ecology;

   Abstract : .... READ MORE

7. 5. Toxicity testing from an ecological perspective : life history and food web studies with cladocerans

   Author : Sanna Koivisto; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : .... READ MORE