Search for dissertations about: "Toxin, bacteria"

Showing result 1 - 5 of 93 swedish dissertations containing the words Toxin, bacteria.

2. 1. Bioinformatics, evolution and revolution in our understanding of toxin-antitoxin systems

   Author : Chayan Kumar Saha; Gemma C. Atkinson; Victoria Shingler; Gipsi Lima Mendez; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Alarmones; Evolution; Gene neighbourhood; Toxin; Antitoxin; molekylärbiologi; Molecular Biology;

   Abstract : Bacteria experience a wide range of natural challenges during their life cycles, to which they must respond and adapt to live. Under stressed conditions such as amino acid starvation, bacteria slow down their growth mechanism by producing small alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively referred to as (p)ppGpp. READ MORE

4. 2. Towards time-resolved molecular interaction assays in living bacteria

   Author : João Crispim Encarnação; Karl Andersson; Marika Nestor; U. Helena Danielson; Hélène Munier-Lehmann; Uppsala universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intracellular Molecular Interactions; Real-Time Cell Binding Assays; Bacteria; LigandTracer; Kinetics; Biokemi; Biochemistry; Biofarmaci; Biopharmaceutics; Medicinsk vetenskap; Medical Science;

   Abstract : Rare and neglected diseases such as multidrug resistant (MDR) tuberculosis, malaria and trypanosomiasis are re-emerging in Europe. New strategies are needed to accelerate drug discovery to fight these pathogens. READ MORE

5. 3. Bacteria and cancer : from toxin delivery to carcinogenesis

   Author : Riccardo Guidi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Epidemiological evidence link certain chronic bacterial infections to a higher risk of cancer development. Induction of an inflammatory circuit and the accumulation of genomic instability are considered mechanisms by which bacteria contribute to malignant transformation. READ MORE

6. 4. Small RNAs, Big Consequences : Post-transcriptional Regulation and Adaptive Immunity in Bacteria

   Author : Mirthe Hoekzema; Gerhart E. H. Wagner; Magnus Lundgren; Kai Papenfort; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; small RNA; sRNA; non-coding RNA; Hfq; gene regulation; post-transcriptional regulation; biofilm; OmrA; OmrB; toxin-antitoxin; TisB; IstR-1; Persisters; CRISPR-Cas; CRISPR-Cas adaptation reporter; Escherichia coli; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Abstract : It is nowadays widely accepted that non-coding RNAs play important roles in post-transcriptional regulation of genes in all kingdoms of life. In bacteria, the largest group of RNA regulators are the small RNAs (sRNAs). READ MORE

7. 5. Toxin production in clostridium difficile

   Author : Sture Karlsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Clostridium difficile is a is a Gram potential human pathogen. It causing symptoms ranging from mild C. difficile associated diarrhea (CDAD) to severe inflammation of the colon including pseudomembranous colitis and fulminant colitis. Over 300 000 and about 10 000 CDAD episodes are diagnosed annually in the USA and Sweden, respectively. READ MORE