Search for dissertations about: "Transactivation domain"

Showing result 16 - 20 of 48 swedish dissertations containing the words Transactivation domain.

  2. 16. Studies on the atypical orphan receptor SHP

    Author : Lotta Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear receptors (NRs) comprise the largest family of transcription factors in eukaryotes and play critical roles in nearly every aspect of vertebrate development and adult physiology. In general, they function as transcriptional regulators that when bound to DNA either activate or suppress target gene expression. READ MORE

  4. 17. Glucocorticoid receptor cross-talk with NF-kappaB and AP-1 : functional role and mechanisms

    Author : Lars-Göran Bladh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glucocorticoid receptor; glucocorticoids; cross-talk; NF-kappaB; AP-1; cell cycle; cell proliferation;

    Abstract : The protein investigated in this thesis is the glucocorticoid receptor (GR), which is a ligand activated transcription factor that belongs to the superfamily of nuclear hormone receptors. The GR contains three functional independent domains, the N-terminal domain containing a major transactivation region, the central DNA binding domain (DBD) and the C-terminal domain that binds the hormone/ligand. READ MORE

  5. 18. Oxygen-dependent regulation of HIF-1alpha expression and function

    Author : Xiaowei Zheng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hypoxia is a state of reduced oxygen levels below normal values. It occurs in the pathophysiology of many diseases and plays important roles in mammalian physiology and development. The hypoxia-inducible factors (HIFs) are transcription factors that mediate adaptive cellular responses to hypoxia by activating the transcription of target genes. READ MORE

  6. 19. Biophysical characterization of protein-protein interactions involving intrinsically disordered proteins

    Author : Ida Nyqvist; Jakob Dogan; Ivarsson Ylva; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Intrinsically disordered proteins; Protein-protein interactions; Disorder-to-order transition; Rate-limiting transition state; Ф-value analysis; NMR relaxation; Side-chain dynamics; Backbone dynamics; Conformational entropy change; Biophysics; biofysik;

    Abstract : Intrinsically disordered proteins and regions (IDPs/Rs) are proteins that do not form stable and well-defined structures in their free states but rather occupy an ensemble of conformations that change over time while still staying functional. They are prevalent in the eukaryotic proteome and are involved in various vital processes in the cell where they often interact with their binding partners through coupled binding and folding reactions. READ MORE

  7. 20. Molecular mechanisms of gene activation by nuclear receptors and their associated coregulators

    Author : Anette Wärnmark; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear receptors (NRs) are ligand-dependent transcription factors. The DNA-bound receptors either positively or negatively regulate transcription of target genes. The receptors regulate transcription through interaction with transcription coregulators and recruitment of components of the basal transcription machinery. READ MORE