Search for dissertations about: "Transactivation domain"

Showing result 21 - 25 of 48 swedish dissertations containing the words Transactivation domain.

  2. 21. Evolution of Interactions Involving Intrinsically Disordered Proteins

    Author : Emma Åberg; Per Jemth; Madan Babu; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered proteins; protein evolution; phylogenetics; ancestral sequence reconstruction; biophysical characterization; NCBD; CID; p53; MDM2; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Biokemi; Biochemistry;

    Abstract : This thesis describes the evolution of intrinsically disordered proteins and their interaction partners. The work presented is a combination of phylogenetic analysis, ancestral reconstruction and biophysical characterization in order to examine the evolutionary trajectory of protein-protein interactions involving disorder. READ MORE

  4. 22. Transcriptional regulation of human nuclear encoded mitochondrial genes

    Author : Ahmed Zaid; Richard Scarpulla; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Abstract : Biogenesis of mammalian mitochondria requires the participation of both nuclear and mitochondrial genes. This thesis presents studies that characterize the common features of several nuclear encoded mitochondrial promoter genes and proposes the identity of factors regulating the transcription and responsible for coordinated, constitutive expression of diverse mammalian oxidative phosphorylation (OXPHOS) genes. READ MORE

  5. 23. Transcription factors PROX1 and p53 in cancer development

    Author : Tamador Elsir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The majority of malignant brain tumors in adults are astrocytic gliomas. These are classified into four malignancy grades according to the World Health Organization (WHO) criteria, including grade I pilocytic astrocytoma, grade II astrocytoma, grade III anaplastic astrocytoma and grade IV glioblastoma. READ MORE

  6. 24. Transcription factors regulating the Btk promoter

    Author : Susanne Müller; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Btk; X-linked agammaglobulinemia; transcription factors; repression; synergism; Sp 1; Sp3; PU.l; Spi-B; genetherapy.;

    Abstract : Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase-related to the Src family of kinases. Mutations in various parts of the gene have been shown to lead to X-linked agammaglobulinemia, an immunodeficiency disease which is characterized by a defect in B-cell development. READ MORE

  7. 25. Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress

    Author : Malin Fladvad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain protein, where it's C-terminal basic helix-loop-helix leucine zipper (bHLH-Zip) domain heterodimerizes with Max to accomplish gene regulatory activity. READ MORE