Search for dissertations about: "Transcription Factor AP-1"

Showing result 1 - 5 of 37 swedish dissertations containing the words Transcription Factor AP-1.

  2. 1. Macrophage Activation and AP-1 in Atherosclerosis

    Author : Maria Stollenwerk; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Proteins; enzymology; Proteiner; enzymologi; Cardiovascular system; carotid plaque; interleukin-1b; caspase-1.; very low-density lipoprotein; fatty acids; activator protein-1; inflammation; Atherosclerosis; nuclear factor-kB; macrophages; tumor necrosis factor;

    Abstract : High levels of very low density lipoprotein (VLDL) and intermediate density lipoprotein (IDL) have been identified as independent risk factors for coronary heart disease. Hypertriglyceridemia is generally associated with an increased expression of inflammatory makers and inflammation is thought to contribute to atherosclerosis and its complications. READ MORE

  4. 2. Exploring the genome-wide impact of transcription factor AP-1 in breast cancer

    Author : Yichin Qiao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : AP-1 plays crucial roles in a wide range of cellular processes in breast cancer. Through the dimeric basic leucine zipper (bZIP) domain, the mammalian AP-1 proteins bind to DNA and form homodimers or heterodimers from the Jun (c-Jun, JunB, JunD), Fos (c-Fos, FosB, Fra1, Fra2), ATF and MAF family members. READ MORE

  5. 3. Alcohol and gene expression in nerve cells with emphasis on transcription factor AP-1

    Author : Ulrik Fried; Institutionen för laboratoriemedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nerve cells; SH-SY5Y; muscarinic receptors; MAPKs; PKC; gene expression; jun; Activating Protein-1; Alcohol; ethanol; CRABP-I; Clinical chemistry; Klinisk kemi;

    Abstract : Alcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. READ MORE

  6. 4. Assessing carotid plaque structure

    Author : Isabel Goncalves; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; Kardiovaskulära systemet; Modified LDL; Antibodies; Lipids; AP-1; Cellularity; Extracellular Matrix; Calcification; Elastin; Stroke; Gray-Scale Median; Echogenicity; Ultrasound; Atherosclerosis; Carotid Plaque;

    Abstract : Atherosclerosis is the leading cause of death and disability in the western world. Its clinical complications include acute myocardial infarction, sudden death and stroke. Thirty to 40 % of all ischemic strokes are caused by a carotid stenosis. READ MORE

  7. 5. Glucocorticoid receptor cross-talk with NF-kappaB and AP-1 : functional role and mechanisms

    Author : Lars-Göran Bladh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glucocorticoid receptor; glucocorticoids; cross-talk; NF-kappaB; AP-1; cell cycle; cell proliferation;

    Abstract : The protein investigated in this thesis is the glucocorticoid receptor (GR), which is a ligand activated transcription factor that belongs to the superfamily of nuclear hormone receptors. The GR contains three functional independent domains, the N-terminal domain containing a major transactivation region, the central DNA binding domain (DBD) and the C-terminal domain that binds the hormone/ligand. READ MORE