Search for dissertations about: "Transcription Factors: genetics"

Showing result 1 - 5 of 86 swedish dissertations containing the words Transcription Factors: genetics.

2. 1. Purification of general RNA polymerase II transcription factors from mouse for studies of proliferation-specific transcription

   Author : Irina Kotova; Lars-Gunnar Larsson; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Genetik; Genetics; Genetik;

   Abstract : Accurate initiation of transcription by RNA polymerase II depends on general transcription factors (GTFs), which include the TATA-binding protein (TBP) and the transcription factors (TF) IIB, IIF, IIE and IIH. In order to reconstitute mouse transcription in vitro, we cloned the genes encoding mouse TFIIB, and both subunits of TFIIE and TFIIF from a mouse cDNA library. READ MORE

4. 2. Familial amyloidosis with polyneuropathy : studies of genetic factors modifying the phenotype of the disease

   Author : Malin Olsson; Ole B Suhr; Lisbeth Tranebjærg; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Familial amyloid polyneuropathy; Amyloidosis; Transthyretin; Allele Frequency; Mitochondria; parent-of-origin; MicroRNA; Single Nucleotide Polymorphism; 3 Untranslated Regions genetics; Medical genetics; Medicinsk genetik; Clinical genetics; Klinisk genetik; genetik; Genetics; klinisk genetik; Clinical Genetics; medicin; Medicine;

   Abstract : Background. Familial Amyloidosis with Polyneuropathy (FAP) is an autosomal dominantly inherited systemic amyloid disease. The disease is caused by mutations in the transthyretin (TTR) gene, where close to 100 different amyloidogenic mutations have been identified. READ MORE

5. 3. Genetic and Genomic Analysis of Transcriptional Regulation in Human Cells

   Author : Mehdi Motallebipour; Claes Wadelius; Gunnar Westin; Dirk Schübeler; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcription; ChIP-chip; ChIP-seq; genome-wide; transcription factors; microsatellite; epigenetic; Medical genetics; Medicinsk genetik;

   Abstract : There are around 20.000 genes in the human genome all of which could potentially be expressed. However, it is obvious that not all of them can be active at the same time. Thus, there is a need for coordination achieved through the regulation of transcription. READ MORE

6. 4. Studies of Budding Yeast Transcription Factors Acting Downstream of Nutrient Signaling Pathways

   Author : Niklas Nordberg; Hans Ronne; Anders Blomberg; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Budding yeast; nutrient signaling; glucose repression; aging; caloric restriction; JmjC; histone demethylation; Mig1; Mig2; Mig3; Gis1; Rph1; Molekylär genetik; Molecular Genetics;

   Abstract : Being able to respond to extracellular cues such as nutrients and growth factors is of vital importance to all living cells. Pathways have therefore evolved which can sense the extracellular status, transmit a signal through the cell and affect gene expression, which ultimately enables adaptation. READ MORE

7. 5. From Single Gene to Whole Genome Studies of Human Transcription Regulation

   Author : Alvaro Rada-Iglesias; Claes Wadelius; Henk Stunnenberg; Uppsala universitet; []
   Keywords : Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

   Abstract : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. READ MORE