Search for dissertations about: "Transthyretin"

Showing result 1 - 5 of 43 swedish dissertations containing the word Transthyretin.

  1. 1. Transthyretin and the transthyretin-related protein: A structural study

    University dissertation from Umeå : Umeå centrum för molekylär patogenes (UCMP) (Teknisk-naturvetenskaplig fakultet)

    Author : Erik Lundberg; A. Elisabeth Sauer-Eriksson; Lennart Sjölin; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Transthyretin-related protein; X-ray crystallography; Protein structure; Amyloidosis; NATURAL SCIENCES Chemistry Biochemistry Structural biology; NATURVETENSKAP Kemi Biokemi Strukturbiologi;

    Abstract : Transthyretin (TTR) is one of several proteins involved in amyloid disease in humans. Unknown conformational changes of the native state of TTR result in aggregation of TTR molecules into amyloid fibrils, which accumulate in extracellular tissues. This may result in different clinical symptoms, e.g. READ MORE

  2. 2. Hereditary transthyretin amyloidosis (ATTR V30M) from genes to genealogy

    University dissertation from Umeå : Umeå Universitet

    Author : Nina Norgren; Ole Suhr; Alda Sousa; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hereditary transthyretin amyloidosis; Familial amyloid polyneuropathy; transthyretin; genealogy; founder effect; miRNA; allele-specific expression; gene expression; liver; medicin; Medicine;

    Abstract : Background: Hereditary transthyretin amyloidosis is an autosomal dominant disease with a reduced penetrance. The most common mutation in Sweden is the V30M mutation in the transthyretin gene. Clustering areas of the disease can be found in Northern Sweden, Portugal, Brazil and Japan, although sporadic cases exist worldwide. READ MORE

  3. 3. Selection of transthyretin amyloid inhibitors

    University dissertation from Umeå : Umeå University

    Author : Irina Iakovleva; Anders Olofsson; Göran Larsson; Bente Westergaard; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transthyretin; TTR; ATTR; TTR-stabilizing drugs; selectivity; medicinsk biokemi; Medical Biochemistry;

    Abstract : Amyloidosis is a group of clinical disorders caused by the aggregation of specific proteins into abnormal extracellular deposits. Today, 31 different proteins have been linked to amyloid diseases including transthyretin-related amyloidosis (ATTR). READ MORE

  4. 4. A Drosophila Disease-Model for Transthyretin-associated Amyloidosis

    University dissertation from Umeå : Molekylärbiologi (Medicinska fakulteten)

    Author : Malgorzata Pokrzywa; Erik Lundgren; Damian Crowther; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transthyretin; amyloid; amyloidosis; Drosophila; transthyretin-associated amyloidosis; Familial amyloid polyneuropathy; neurodegeneration; serum amyloid P component; Non-steroidal Anti-Inflammatory Drugs; drug screens; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi;

    Abstract : Amyloidoses comprise a group of gain-of-toxic function protein misfolding diseases, in which normally soluble proteins in their functional state undergo conformational changes into highly organized and generally intractable thread-like aggregates, termed amyloid fibrils. These structures accumulate predominantly in the extracellular space but growing evidence suggests that amyloids may start to form intracellularly. READ MORE

  5. 5. Structural and functional properties of transthyretin

    University dissertation from Umeå : Umeå centrum för molekylär patogenes (UCMP) (Teknisk-naturvetenskaplig fakultet)

    Author : Anders Karlsson; A. Elisabeth Sauer-Eriksson; Salam Al-Karadaghi; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Amyloidosis; X-ray crystallography; Protein structure; Protein; NATURAL SCIENCES Chemistry Biochemistry Structural biology; NATURVETENSKAP Kemi Biokemi Strukturbiologi;

    Abstract : The hereditary transthyretin (TTR) amyloidoses are rare, and in severe cases, fatal disorders caused by mutations in the TTR gene. The clinical picture is diverse, involving neuropathies and myopathies, and mainly depends on the causative mutation and the sites and rates of amyloid deposition. READ MORE