Search for dissertations about: "Treg"

Showing result 11 - 15 of 88 swedish dissertations containing the word Treg.

  2. 11. Lineage stability and effector function of CD4+FOXP3+ regulatory T cells

    Author : Christina Seitz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This work focuses on regulatory T (Treg) cell biology in the context of defining the role of forkhead box protein 3 (FOXP3) isoform expression and Treg mediated suppression via CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Treg cells are crucial in maintaining immunological tolerance and they in part act by suppressing dendritic cells (DCs). READ MORE

  4. 12. Regulatory T cells in type 1 diabetes: the role of IL-35 in counteracting the disease

    Author : Kailash Singh; Thomas Mandrup-Poulsen; Uppsala universitet; []
    Keywords : IL-35; regulatory T cells; type 1 diabetes; LADA; kidney and diabetic nephropathy; Medicinsk vetenskap; Medical Science; Immunologi; Immunology; Endocrinology and Diabetology; Endokrinologi och Diabetologi;

    Abstract : Type 1 diabetes (T1D) is etiologically considered as an autoimmune disease, where insulin-producing β-cells are damaged by autoimmune attacks. Regulatory T (Treg) cells are immune homeostasis cells. In the present thesis I aimed to investigate the role of Treg cells and other immune cells in the early development of T1D. READ MORE

  5. 13. Inhibition of T cell responses to autoantigens and allergens by CD25+ regulatory T cells from thymus, cord and adult blood

    Author : Kajsa Wing; Göteborgs universitet; []
    Keywords : Tolerance; CD25 regulatory T cells; adult peripheral blood; cord blood; thymus; autoimmune disease; allergy;

    Abstract : Autoimmune diseases and allergies are a growing problem in the western world today. Tolerance is primarily established by clonal deletion in the thymus. Despite this auto-reactive T cells are normally present in most individuals, which suggests that mechanisms of peripheral tolerance operate to silence potentially pathogenic T cells. READ MORE

  6. 14. Reign in Blood : Immune Regulation in Type 1 Diabetes

    Author : Mikael Pihl; Rosaura Casas; Johnny Ludvigsson; Marianne Quiding-Järbrink; Linköpings universitet; []
    Keywords : ;

    Abstract : Type 1 Diabetes (T1D) is an autoimmune disease resulting in insulin deficiency as a result ofautoimmune destruction of pancreatic β-cells. Preserving β-cell function in patients with T1D would be of great benefit since patients with sustained endogenous insulin secretion are known to suffer less from secondary complications due to hyperglycemia. READ MORE

  7. 15. Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function

    Author : Filip Ahlmanner; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colon cancer; regulatory T cells; CD39; adenosine; immune checkpoint molecules; immunosuppression; MAIT cells; cytokines; cancer-specific survival;

    Abstract : In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the balance between these two counteracting forces partly determines patient outcome. READ MORE