Search for dissertations about: "Trypanosoma cruzi"

Showing result 11 - 15 of 19 swedish dissertations containing the words Trypanosoma cruzi.

  2. 11. Genome characterisation and mobility investigation in trypanosomes

    Author : Carole Branche; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma brucei - Trypanosoma cruzi - karyotype - genome organisation -flageflum mobility - RNAi - functional studies.;

    Abstract : Trypanosomes are uni-flagellated protozoa responsible for some of the most debilitating human infections such as Chagas disease (Trypanosoma cruzi) and sleeping sickness (Trypanosoma brucei). Unravelling their genome organisation and their biology would improve our basic knowledge and could contribute to find new drug target specific to the species. READ MORE

  4. 12. Immunopathogenesis of experimental Chagas' disease

    Author : Dan Sunnemark; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma cruzi; Chagas disease; pathology; cytokines; vasculitis; atherosclerosis;

    Abstract : Chagas' disease is a serious, life-threatening disease caused by the protozoan parasite Trypanosoma cruzi in South and Central America. Neither vaccine candidate(s) nor efficient, nontoxic chemotherapeutical agents exist at the present time. READ MORE

  5. 13. Genomic feature identification in trypanosomatid parasites

    Author : Daniel Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma cruzi; genome sequence; bioinformatics; gene finding; Trypanosoma brucei; Leishmania major; strand asymmetry; trans splicing; polyadenylation; post-transcriptional control; uAUGs.;

    Abstract : The trypanosomatid parasites cause death and suffering, among humans as well as livestock. Current drugs lack efficacy and cause severe side effects, and no vaccines are available. Increased knowledge of the biology of the parasites is vital for the development of new drugs. READ MORE

  6. 14. Experimental Chagas disease

    Author : John Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma cruzi; NK cells; cytotoxicity; IFN-gamma; IL-12; IFN-alpha beta; Chagas disease; polymyositis; myocarditis; genotype dependence and Toll-like receptors.;

    Abstract : The main focus of this thesis was to develop and utilise experimental models using the protozoan parasite Trypanosoma cruzi. We were especially interested in studying the activation of NK cells early after T. cruzi infection and what factors that predispose to a chronic inflammatory disease after T. cruzi infection. READ MORE

  7. 15. Comparative genomics and molecular characterization of N-alpha acetyltransferase in trypanosomes for drug target identification

    Author : Stephen Ochaya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Trypanosoma cruzi and Trypanosoma brucei are flagellated protozoan parasites that cause Chagas disease and African trypanosomiasis in Latin American and African countries, respectively. Currently, over 8 million people are infected with T. cruzi and about 25 million more are at risk. About half a million people are affected by T. READ MORE