Search for dissertations about: "Tumörmikromiljö"

Showing result 11 - 15 of 57 swedish dissertations containing the word Tumörmikromiljö.

  2. 11. Adaptation to microenvironmental stress in glioblastoma. Mechanistic studies and potential targets

    Author : Myriam Cerezo-Magaña; Tumörmikromiljö; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glioblastoma; Tumor microenvironment; EVs; Proteoglycans; Tumor Surfaceome;

    Abstract : Although the overall mortality in cancer is steadily decreasing, major groups of patients still respond poorly to available treatments. The key clinical challenge addressed in the present thesis work relates to the inherent adaptive capacity of glioblastoma (GBM) tumors, resulting in treatment resistance and dismal prognosis. READ MORE

  4. 12. Mechanistic studies on the role of extracellular vesicles in the tumor microenvironment

    Author : Helena Christianson; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microvesicle; exosome; Key words Extracellular vesicle; glioblastoma; hypoxia; angiogenesis; acidosis; proteoglycan; endocytosis; carbonic anhydrase IX; biomarker.;

    Abstract : The transition from normal into malignant cells with acquired uncontrolled growth is a process where cancer cells viciously develop adaptive strategies to overcome microenvironmental and metabolic stress. Hypoxia, or deficient oxygen supply, is a common feature of the expanding tumor which alters cell metabolism and consecutively causes lowered intracellular pH. READ MORE

  5. 13. Patients in Clinical Cancer Trials. Information, Understanding and Decision-Making

    Author : Pia Dellson; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical Cancer Trials; Informed Consent Documents; Patient Understanding; Decision-Making;

    Abstract : The informed consent process for clinical trials (CTs) is complex. Patients must be able to understand the information given to be able to make an informed decision. READ MORE

  6. 14. Fine needle aspiration diagnosis of spindle cell tumors of soft tissue, including the use of ancillary methods, and correlation with clinical data

    Author : Henryk Domanski; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patologi allmän ; patologisk anatomi; General pathology; pathological anatomy; spindle cell lipoma; soft tissue; spindle cell tumors; Medicine human and vertebrates ; Medicin människa och djur ; schwannoma; neurilemoma; leiomyosarcoma; immunocytochemistry; FNA; fine needle aspiration; dermatofibrosarcoma protuberans; elastofibroma dorsi; Cytology; electron microscopy;

    Abstract : Fine needle aspiration cytology (FNAC) is gaining increased popularity in the diagnosis of soft tissue lesions. FNAC used as a primary examination method to obtain a morphologic diagnosis, has been part of the diagnostic work-up of patients admitted to the Musculoskeletal Tumor Center of the Lund University Hospital since 1972. READ MORE

  7. 15. On the Role of the Tumor Suppressor p53 in Leukemic Cell Differentiation

    Author : Mats Ehinger; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; p53; Tumor Suppressor Genes; Leukemia; Differentiation; extracellular fluids; Hematologi; extracellulära vätskor;

    Abstract : Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. READ MORE