Search for dissertations about: "Tumor suppressor genes"

Showing result 16 - 20 of 195 swedish dissertations containing the words Tumor suppressor genes.

  2. 16. Delection mapping of human 3p in major epithelial types of cancer and fine localization of candidate tumor suppressor genes

    Author : Jian Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Tumor suppressor gene; epithelial carcinoma; human chromosome 3p;

    Abstract : Allele loss and deletion mapping using microsatellite markers and the detection of homozygous deletions represented until now the most powerful method to localize potential TSGs. Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by chromosome 3p deletions are detected in almost 100% of renal cell carcinoma (RCC), small (SCLCs) and more than 90% of non-small (NSCLC) cell lung cancers. READ MORE

  4. 17. Localization and characterization of genes involved in parathyroid tumor development

    Author : Lars Forsberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Parathyroid; Hyperparathyroidsm; MEN1; HRPT2; Menin; Parafibromin; Chromosome 11; Chromosome 1;

    Abstract : The overall goal of this thesis has been to identify new genes and characterize them regarding the involvement in parathyroid tumor development. The parathyroid glands are responsible for the control of calcium homeostasis. Parathyroid tumors usually have a benign growth pattern, with less than 1% of the tumors being malignant. READ MORE

  5. 18. TGF-beta signaling in cancer

    Author : Erik Johansson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TGF-β; proliferation; cancer; tumor suppressor; diffuse-type gastric carcinoma; neuroblastoma; nuclear receptor TLX; cancer stem cell; angiogenesis; ABCG2; VHL; HIF2α; hypoxia; Smad3;

    Abstract : Transforming Growth Factor Beta (TGF-β) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-β functions as a tumor suppressor, mainly due to its inhibitory effect on cellular growth, but during cancer progression, mutations in TGF-β signal components switches TGF-β into a promoter of cancer cell proliferation, survival and metastasis. READ MORE

  6. 19. Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach

    Author : Santhilal Subhash; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Computational biology; Long noncoding RNAs; Chromatin; S-phase; Cell cycle; sperm; Epigenetics; Histone; cancer; oncogene; Tumor suppressor; DNA methylation; Histone modifications; Chromatin remodelers; lncRNAs; lincRNAs;

    Abstract : One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis phase, the DNA in the cell makes a new copy to pass on genetic information to the daughter cells. READ MORE

  7. 20. Exploring novel roles of tumor pericytes

    Author : Jong Wook Hong; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tumor biology has been extensively studied over the last few decades, with a principal focus on how neoplastic cells obtain cellular immortality. A number of oncogenes and tumor suppressor genes have been uncovered that regulate cancerous transformation. READ MORE