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Showing result 1 - 5 of 21 swedish dissertations matching the above criteria.

  2. 1. Activity of tumor-antigens in polyomavirus replication

    Author : Hongyun Li; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Tumor-Antigens; DNA Replication; Cell-cycle; Phosphorylation; J-domain; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Abstract : Polyomavirus replication needs an active cell environment, and the viral DNA replication is cell cycle regulated. Tumor antigens (T-antigens) of mouse polyomavirus, especially large T-antigen, are necessary for the replication. READ MORE

  4. 2. Immunological aspects of papillary thyroid carcinoma

    Author : Steven D. Lucas; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Papillary thyroid carcinoma; immunology; tumor antigens; RET proto-oncogene; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : Papillary thyroid carcinoma (PTC) is a puzzling disease. Although approximately 70% of patients with PTC have regional lymph node metastases at initial surgery, the long term survival is over 95%. READ MORE

  5. 3. Tumor recognition by cytotoxic T cells : definition of new tumor antigens and the effect of interleukin-10 on antigen presentation

    Author : Flavio Salazar-Onfray; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor antigens against which T cell responses have been demonstrated most frequently are not tumor specific but are also expressed on normal tissues. This observation has been interpreted as evidence for breaking of immunological tolerance to normal cellular proteins. READ MORE

  6. 4. The HER2/neu oncoprotein and dendritic cells in immunity against tumors

    Author : Yang Rongcun; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HER2 neu; dendritic cells; ovarian carcinoma; apoptosis;

    Abstract : It is now well established that small peptide epitopes bound to the major histocompatibility complex (MHC), derived from processed proteins synthesized by the tumor cells, can be recognized as antigens by cytotoxic T lymphocytes (CTLs). A number of tumor antigens recognized by CTLs on human melanomas have been defined, but less is known about antigens from other tumor types. READ MORE

  7. 5. Cancer therapy using viral and bacterial proteins as vectors for vaccines or as carriers of cytostatics

    Author : Mathilda Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : New cancer therapies are urgently needed, since available treatment options today have negative side effects, and cure only about half of the patients with invasive cancer. One, relatively new, option is to vaccinate against cancer, by introducing an antigen that is present on the tumor cells into the patient to stimulate specific immunity against the tumor. READ MORE